Beyond receptor expression levels: The relevance of target accessibility in ligand-directed pharmacodelivery systems
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作者:
Ozawa, Michael G.
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机构:Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Ozawa, Michael G.
Zurita, Amado J.
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机构:Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Zurita, Amado J.
Dias-Neto, Emmanuel
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机构:Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Dias-Neto, Emmanuel
Nunes, Diana N.
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机构:Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Nunes, Diana N.
Sidman, Richard L.
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机构:
Harvard Univ, Sch Med, Boston, MA 02115 USA
Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02115 USAUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Sidman, Richard L.
[3
,4
]
Gelovani, Juri G.
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Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Gelovani, Juri G.
[2
]
Arap, Wadih
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Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Arap, Wadih
[1
]
Pasqualini, Renata
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Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
Pasqualini, Renata
[1
]
机构:
[1] Univ Texas MD Anderson Canc Ctr, Dept Genitourinary Med Oncol, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77030 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
[4] Harvard Univ, Inst Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02115 USA
For development of a new ligand-directed pharmacology, it is critical to measure delivery of targeted drug ligands via molecular imaging or diagnostic readouts (termed theranostics). Combinatorial peptide libraries serve as unbiased functional screens that can identify specific peptides targeting cell-surface receptors accessible to the circulation. As candidate drug leads, such peptides provide motifs likely to modify ligand-receptor interactions and downstream signal transduction pathways. This strategy is synergistic with genomic and proteomic approaches and has yielded insights into the specialized nature of the target tissue microenvironment. However, for this vision to be realized, one must look, as recent literature suggests, beyond receptor levels and critically analyze ligand accessibility as a key determinant in pharmacodelivery systems.
机构:
Univ Calif Los Angeles, Semel Inst Neuropsychiat & Human Behav, Hatos Ctr Neuropharmacol, Los Angeles, CA 90024 USA
Univ Calif Los Angeles, Shirley & Stefan Hatos Ctr Neuropharmacol, Los Angeles, CA 90024 USAUniv Calif Los Angeles, Semel Inst Neuropsychiat & Human Behav, Hatos Ctr Neuropharmacol, Los Angeles, CA 90024 USA
Pradhan, Amynah A.
Smith, Monique L.
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Univ Calif Los Angeles, Shirley & Stefan Hatos Ctr Neuropharmacol, Los Angeles, CA 90024 USAUniv Calif Los Angeles, Semel Inst Neuropsychiat & Human Behav, Hatos Ctr Neuropharmacol, Los Angeles, CA 90024 USA
Smith, Monique L.
Kieffer, Brigitte L.
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机构:
Univ Calif Los Angeles, Shirley & Stefan Hatos Ctr Neuropharmacol, Los Angeles, CA 90024 USA
Univ Strasbourg, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, Illkirch Graffenstaden, FranceUniv Calif Los Angeles, Semel Inst Neuropsychiat & Human Behav, Hatos Ctr Neuropharmacol, Los Angeles, CA 90024 USA
Kieffer, Brigitte L.
Evans, Christopher J.
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Univ Calif Los Angeles, Shirley & Stefan Hatos Ctr Neuropharmacol, Los Angeles, CA 90024 USAUniv Calif Los Angeles, Semel Inst Neuropsychiat & Human Behav, Hatos Ctr Neuropharmacol, Los Angeles, CA 90024 USA