Poly(ethylene glycol)-containing hydrogels in drug delivery

被引：460

作者：

Peppas, NA ^{[1
]}

Keys, KB ^{[1
]}

Torres-Lugo, M ^{[1
]}

Lowman, AM ^{[1
]}

机构：

[1] Purdue Univ, Sch Chem Engn, Biomat & Drug Delivery Labs, W Lafayette, IN 47907 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 1999年 / 62卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

poly(ethylene glycol); gels; drug delivery; protein delivery; star polymers;

D O I：

10.1016/S0168-3659(99)00027-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of hydrogels as carriers for protein delivery has been a subject of significant recent research. In our recent work, we have shown that diffusion controlled delivery of proteins from hydrogels containing poly(ethylene glycol) (PEG) can be possible and controlled by the three-dimensional structure. In addition, a number of these hydrogel carriers are mucoadhesive and can be used for protein delivery. PEG star polymer gels have also been prepared by gamma-irradiation and have been used for protein delivery with and without molecular imprinting. The presence of a large number of functional groups in a small volume makes these polymers important for use in biological and pharmaceutical applications. PEG star polymer hydrogels were synthesized using gamma-irradiation and were characterized using swelling techniques. Equilibrium swelling studies were conducted to investigate the effects of molecular weight, number of star arms, concentration, and radiation dose. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：81 / 87

页数：7

共 21 条

[1]

[Anonymous], CENTRAL HILLS REGION

[2]

Antonsen K.P., 1992, Poly (Ethylene Glycol) Chemistry, P15, DOI [10.1007/978-1-4899-0703-5_2, DOI 10.1007/978-1-4899-0703-5_2]

[3] POLY(ETHYLENE OXIDE) (PEO) AND DIFFERENT MOLECULAR-WEIGHT PEO BLENDS MONOLITHIC DEVICES FOR DRUG RELEASE [J].

APICELLA, A ;

CAPPELLO, B ;

DELNOBILE, MA ;

LAROTONDA, MI ;

MENSITIERI, G ;

NICOLAI, L .

BIOMATERIALS, 1993, 14 (02) :83-90

[4]

APICELLA A, 1994, ACS SYM SER, V545, P111

[5]

Belcheva N, 1996, MACROMOL SYMP, V103, P193

[6]

Bromberg L, 1996, J APPL POLYM SCI, V59, P459

[7]

GNANOU Y, 1988, MAKROMOL CHEM, V189, P2885

[8]

Graham N. B., 1987, HYDROGELS MED PHARM, P95

[9] Hydrogels prepared by electron irradiation of poly(ethylene oxide) in water solution: Unexpected dependence of cross-link density and protein diffusion coefficients on initial PEO molecular weight [J].

Kofinas, P ;

Athanassiou, V ;

Merrill, EW .

BIOMATERIALS, 1996, 17 (15) :1547-1550

[10] Analysis of the complexation/decomplexation phenomena in graft copolymer networks [J].

Lowman, AM ;

Peppas, NA .

MACROMOLECULES, 1997, 30 (17) :4959-4965

← 1 2 3 →