Neural Stem Cells and Methods for Their Generation From Induced Pluripotent Stem Cellsin vitro

被引：64
作者：
Galiakberova, Adelya A. [1 ,2 ]
Dashinimaev, Erdem B. [2 ,3 ]
机构：
[1] Lomonosov Moscow State Univ, Fac Biol, Moscow, Russia
[2] Pirogov Russian Natl Res Med Univ, Ctr Precis Genome Editing & Genet Technol Biomed, Moscow, Russia
[3] Russian Acad Sci, Koltzov Inst Dev Biol, Moscow, Russia
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2020年 / 8卷
关键词：
pluripotent stem cells; ESC; iPSC; neural stem cells; NSC; neurogenesis; regenerative medicine; CENTRAL-NERVOUS-SYSTEM; RADIAL GLIAL-CELLS; PROGENITOR CELLS; SONIC HEDGEHOG; SELF-RENEWAL; IN-VITRO; NEURONAL DIFFERENTIATION; SUBVENTRICULAR ZONE; CORTICAL-NEURONS; GERMINAL ZONE;
D O I：
10.3389/fcell.2020.00815
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Neural stem cells (NSCs) provide promising approaches for investigating embryonic neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and for designing drug-screening systems. Such cells also have an application in regenerative medicine. The most convenient and acceptable source of NSCs is pluripotent stem cells (embryonic stem cells or induced pluripotent stem cells). However, there are many different protocols for the induction and differentiation of NSCs, and these result in a wide range of neural cell types. This review is intended to summarize the knowledge accumulated, to date, by workers in this field. It should be particularly useful for researchers who are beginning investigations in this area of cell biology.
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页数：20
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