New players on the piRNA field

被引：5

作者：

Ninova, Maria ^{[1
]}

Fejes Toth, Katalin ^{[1
]}

机构：

[1] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2020年 / 27卷 / 09期

关键词：

DNA METHYLATION; REVEALS;

D O I：

10.1038/s41594-020-0484-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear piRNA pathway safeguards genome integrity in the germline by silencing transposable elements. Three recent studies have identified new players in the mammalian pathway. Two of these, TEX15 and SPOCD1, might provide a link between piRNA-guided complexes that recognize genomic targets and the molecular machinery that induces DNA methylation and transcriptional repression during mouse spermatogenesis.

引用

页码：777 / 779

页数：3

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