Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

被引:47
作者
Chen, Xiaofeng [1 ]
Lu, Hong [1 ]
Rateri, Debra L. [1 ]
Cassis, Lisa A. [2 ]
Daugherty, Alan [1 ]
机构
[1] Univ Kentucky, Saha Cardiovasc Res Ctr, Lexington, KY 40536 USA
[2] Univ Kentucky, Dept Mol & Biomed Pharmacol, Lexington, KY 40536 USA
基金
美国国家卫生研究院;
关键词
SMOOTH-MUSCLE-CELLS; MARFAN-SYNDROME; MOUSE MODEL; RECEPTOR; MICE; LOSARTAN; SYSTEM; GAMMA; PROGRESSION; INHIBITION;
D O I
10.1016/j.coph.2013.01.002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Angiotensin II (AngII) has been invoked as a principal mediator for the development and progression of both thoracic and abdominal aortic aneurysms. While there is consistency in experimental and clinical studies that overactivation of the renin angiotensin system promotes aortic aneurysm development, there are many unknowns regarding the mechanistic basis underlying AngII-induced aneurysms. Interactions of AngII with TGF-beta in both thoracic and abdominal aortic aneurysms have been the focus of recent studies. While these studies have demonstrated profound effects of manipulating TGF-beta activity on AngII-induced aortic aneurysms, they have also led to more questions regarding the interactions between AngII and this multifunctional cytokine. This review compiled the recent literature to provide insights into understanding the potentially complex interactions between AngII and TGF-beta in the development of aortic aneurysms.
引用
收藏
页码:180 / 185
页数:6
相关论文
共 35 条
  • [1] Transforming growth factor-βs and vascular disorders
    Bobik, Alex
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (08) : 1712 - 1720
  • [2] Angiotensin II blockade and aortic-root dilation in Marfan's syndrome
    Brooke, Benjamin S.
    Habashi, Jennifer P.
    Judge, Daniel P.
    Patel, Nishant
    Loeys, Bart
    Dietz, Harry C., III
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (26) : 2787 - 2795
  • [3] Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice
    Daugherty, Alan
    Rateri, Debra L.
    Charos, Israel F.
    Owens, A. Phillip, III
    Howatt, Deborah A.
    Cassis, Lisa A.
    [J]. CLINICAL SCIENCE, 2010, 118 (11-12) : 681 - 689
  • [4] Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms
    Gomez, Delphine
    Coyet, Aurelie
    Ollivier, Veronique
    Jeunemaitre, Xavier
    Jondeau, Guillaume
    Michel, Jean-Baptiste
    Vranckx, Roger
    [J]. CARDIOVASCULAR RESEARCH, 2011, 89 (02) : 446 - 456
  • [5] Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism
    Habashi, Jennifer P.
    Doyle, Jefferson J.
    Holm, Tammy M.
    Aziz, Hamza
    Schoenhoff, Florian
    Bedja, Djahida
    Chen, YiChun
    Modiri, Alexandra N.
    Judge, Daniel P.
    Dietz, Harry C.
    [J]. SCIENCE, 2011, 332 (6027) : 361 - 365
  • [6] Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    Habashi, JP
    Judge, DP
    Holm, TM
    Cohn, RD
    Loeys, BL
    Cooper, TK
    Myers, L
    Klein, EC
    Liu, GS
    Calvi, C
    Podowski, M
    Neptune, ER
    Halushka, MK
    Bedja, D
    Gabrielson, K
    Rifkin, DB
    Carta, L
    Ramirez, F
    Huso, DL
    Dietz, HC
    [J]. SCIENCE, 2006, 312 (5770) : 117 - 121
  • [7] Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice
    Holm, Tammy M.
    Habashi, Jennifer P.
    Doyle, Jefferson J.
    Bedja, Djahida
    Chen, YiChun
    van Erp, Christel
    Lindsay, Mark E.
    Kim, David
    Schoenhoff, Florian
    Cohn, Ronald D.
    Loeys, Bart L.
    Thomas, Craig J.
    Patnaik, Samarjit
    Marugan, Juan J.
    Judge, Daniel P.
    Dietz, Harry C.
    [J]. SCIENCE, 2011, 332 (6027) : 358 - 361
  • [8] Transforming Growth Factor-β Signaling in Myogenic Cells Regulates Vascular Morphogenesis, Differentiation, and Matrix Synthesis
    Jaffe, Mia
    Sesti, Casilde
    Washington, Ida M.
    Du, Liang
    Dronadula, Nagadhara
    Chin, Michael T.
    Stolz, Donna B.
    Davis, Elaine C.
    Dichek, David A.
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012, 32 (01) : E1 - U26
  • [9] Interferon-γ and the Interferon-Inducible Chemokine CXCL10 Protect Against Aneurysm Formation and Rupture
    King, Victoria L.
    Lin, Alexander Y.
    Kristo, Fjoralba
    Anderson, Thomas J. T.
    Ahluwalia, Neil
    Hardy, Gregory J.
    Owens, A. Phillip, III
    Howatt, Deborah A.
    Shen, Dongxiao
    Tager, Andrew M.
    Luster, Andrew D.
    Daugherty, Alan
    Gerszten, Robert E.
    [J]. CIRCULATION, 2009, 119 (03) : 426 - 435
  • [10] In Vivo Characterization of a New Abdominal Aortic Aneurysm Mouse Model With Conventional and Molecular Magnetic Resonance Imaging
    Klink, Ahmed
    Heynens, Joeri
    Herranz, Beatriz
    Lobatto, Mark E.
    Arias, Teresa
    Sanders, Honorius M. H. F.
    Strijkers, Gustav J.
    Merkx, Maarten
    Nicolay, Klaas
    Fuster, Valentin
    Tedgui, Alain
    Mallat, Ziad
    Mulder, Willem J. M.
    Fayad, Zahi A.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 58 (24) : 2522 - 2530