Design of a high-throughput microphysiometer

被引：0

作者：

Verhaegen, K ^{[1
]}

Van Gerwen, P ^{[1
]}

Baert, K ^{[1
]}

Hermans, L ^{[1
]}

Mertens, R ^{[1
]}

Luyten, W ^{[1
]}

机构：

[1] IMEC, B-3001 Heverlee, Belgium

来源：

BIOCALORIMETRY: APPLICATIONS OF CALORIMETRY IN THE BIOLOGICAL SCIENCES | 1998年

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This chapter reports on the development of a micromachined thermoelectric flow calorimeter. Its reaction chamber volume is 5 mu l housing approximately 1 million biological cells. We have optimized the design based on equal weight assignment to signal, signal-to-noise ratio and time constant. Calculations predict a sensitivity of 200 V W-1 and a time constant of 50 ms. Its minimal volume and small time constant make it applicable in modern drug screening. The choice of materials and dimensions is a function of the biocompatibility needed in the device.

引用

页码：225 / 231

页数：7

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