Real-Time Monitoring of the Effectiveness of Six COVID-19 Vaccines against Laboratory-Confirmed COVID-19 in Hungary in 2021 Using the Screening Method

被引:6
作者
Horvath, Judit K. [1 ,2 ,3 ]
Ferenci, Tamas [2 ,3 ,4 ,5 ]
Ferenczi, Annamaria [1 ,2 ,3 ]
Turi, Gergo [1 ,2 ,3 ]
Rost, Gergely [2 ,3 ,6 ]
Oroszi, Beatrix [1 ,2 ,3 ]
机构
[1] Semmelweis Univ, Epidemiol & Surveillance Ctr, H-1085 Budapest, Hungary
[2] Math Modelling & Epidemiol Task Force, H-1085 Budapest, Hungary
[3] Natl Lab Hlth Secur, H-6720 Szeged, Hungary
[4] Obuda Univ, Physiol Controls Res Ctr, H-1034 Budapest, Hungary
[5] Corvinus Univ Budapest, Dept Stat, H-1093 Budapest, Hungary
[6] Univ Szeged, Bolyai Inst, H-6720 Szeged, Hungary
关键词
vaccine effectiveness; screening method; COVID-19; SARS-CoV-2; surveillance; Hungary; waning immunity; VACCINATION; EFFICACY;
D O I
10.3390/vaccines10111824
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Several studies have reported the waning effectiveness of COVID-19 vaccines. This study aims to demonstrate the applicability of the screening method for estimating vaccine effectiveness (VE) in a pandemic. We report VE in Hungary, estimated with the screening method, in 2021, covering a period of Alpha and the Delta variant, including the booster dose roll-out. Hungary is in a unique position to use six different vaccines in the same population. All vaccines provided a high level of protection initially, which declined over time. While the picture is different in each age group, the waning of immunity is apparent for all vaccines, especially in the younger age groups and the Sinopharm, Sputnik-V, and AstraZeneca vaccines, which performed similarly. This is clearly reversed by booster doses, more prominent for those three vaccines, where the decline in protection is more evident. Overall, two vaccines, Pfizer/BioNTech and Moderna, tend to produce the best results in all age groups, even with waning immunity considered. Using the screening method in future pandemic waves is worthwhile, especially in countries struggling with a lack of resources or when there is a need to deliver VE results within a short timeframe due to urgent decision-making.
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页数:10
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