Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

被引：220
|
作者：
Callmann, Cassandra E. [1 ]
Barback, Christopher V. [2 ]
Thompson, Matthew P. [1 ]
Hall, David J. [2 ]
Mattrey, Robert F. [2 ]
Gianneschi, Nathan C. [1 ]
机构：
[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 31期
关键词：
drug delivery; enzyme-responsive; nanomaterials; self-assembly; stimuli-responsive; OPENING METATHESIS POLYMERIZATION; CELL-PENETRATING PEPTIDES; OLEFIN METATHESIS; DRUG-DELIVERY; INTRATUMORAL CHEMOTHERAPY; ANTITUMOR-ACTIVITY; AMINOPEPTIDASE N; LUNG-CANCER; MOUSE MODEL; CATALYSTS;
D O I：
10.1002/adma.201501803
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4611 / 4615
页数：5
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