The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily

被引:168
作者
Changeux, Jean-Pierre [1 ,2 ]
机构
[1] Coll France, F-75005 Paris, France
[2] Inst Pasteur, F-75724 Paris 15, France
关键词
AFFINITY BINDING-SITE; MARMORATA ELECTRIC ORGAN; MEMBRANE-FRAGMENTS RICH; IN-VITRO EXCITATION; X-RAY-STRUCTURE; CHOLINERGIC-RECEPTOR; TORPEDO-MARMORATA; ALPHA-SUBUNIT; DELTA-SUBUNIT; ELECTROPHORUS-ELECTRICUS;
D O I
10.1074/jbc.R112.407668
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A critical event in the history of biological chemistry was the chemical identification of the first neurotransmitter receptor, the nicotinic acetylcholine receptor. Disciplines as diverse as electrophysiology, pharmacology, and biochemistry joined together in a unified and rational manner with the common goal of successfully identifying the molecular device that converts a chemical signal into an electrical one in the nervous system. The nicotinic receptor has become the founding father of a broad family of pentameric membrane receptors, paving the way for their identification, including that of the GABA(A) receptors.
引用
收藏
页码:40207 / 40215
页数:9
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