ARRHYTHMIAS The multifaceted cardiac sodium channel and its clinical implications

被引：9

作者：

Chockalingam, Priya

Wilde, Arthur ^{[1
,2
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Heart Failure Res Ctr, NL-1105 AZ Amsterdam, Netherlands

来源：

HEART | 2012年 / 98卷 / 17期

关键词：

LONG-QT SYNDROME; BRUGADA-SYNDROME; SCN5A; MUTATIONS; DEATH; CHANNELOPATHIES; FIBRILLATION;

D O I：

10.1136/heartjnl-2012-301784

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cardiac sodium channel plays an integral role in the evolution of our understanding of the aetiopathogenesis of sudden and unexpected young deaths. New and significant genetic mutations associated with a wide array of potentially lethal clinical conditions are being discovered at a rapid pace, thanks to unsurpassed advances in molecular techniques and medical acumen. A precise understanding of the structure and functions of the ion channels, combined with knowledge of the associated pathological manifestations, will enable appropriate diagnostic and therapeutic decisions to be made for this challenging group of disorders.

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收藏

页码：1318 / 1324

页数：7

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