Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

被引：71

作者：

Webre, Jody M. ^{[1
]}

Hill, James M. ^{[1
,2
,3
,4
]}

Nolan, Nicole M. ^{[1
,5
]}

Clement, Christian ^{[1
]}

McFerrin, Harris E. ^{[6
]}

Bhattacharjee, Partha S. ^{[1
,6
]}

Hsia, Victor ^{[7
]}

Neumann, Donna M. ^{[1
,2
,8
]}

Foster, Timothy P. ^{[3
]}

Lukiw, Walter J. ^{[1
,4
]}

Thompson, Hilary W. ^{[1
,4
,9
]}

机构：

[1] Louisiana State Univ, Dept Ophthalmol, Hlth Sci Ctr, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Dept Pharmacol, Hlth Sci Ctr, New Orleans, LA 70112 USA

[3] Louisiana State Univ, Dept Microbiol, Hlth Sci Ctr, New Orleans, LA 70112 USA

[4] Louisiana State Univ, Ctr Neurosci, Hlth Sci Ctr, New Orleans, LA 70112 USA

[5] Tulane Univ, Coll Sci & Engn, New Orleans, LA 70118 USA

[6] Xavier Univ Louisiana, Dept Biol, New Orleans, LA 70125 USA

[7] Univ Maryland Eastern Shore, Sch Pharm & Hlth Profess, Princess Anne, MD 21853 USA

[8] Louisiana State Univ, Dept Genet, Hlth Sci Ctr, New Orleans, LA 70112 USA

[9] Louisiana State Univ, Dept Biostat, Sch Publ Hlth, Hlth Sci Ctr, New Orleans, LA 70112 USA

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年

基金：

美国国家卫生研究院;

关键词：

HERPES-SIMPLEX-VIRUS; CORNEAL EPITHELIAL LESIONS; CAMP RESPONSE ELEMENT; IN-VIVO REACTIVATION; TYPE-1; LATENCY; TRIGEMINAL GANGLIA; APOLIPOPROTEIN-E; TRANSCRIPT GENE; STROMAL KERATITIS; OCULAR REACTIVATION;

D O I：

10.1155/2012/612316

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery. Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatments of recurrent ocular disease. Animal models have been used for over sixty years to investigate our concepts and hypotheses of HSV-1 diseases. In this paper we present descriptions and examples of rabbit and mouse eye models of HSV-1 latency, reactivation, and recurrent diseases. We summarize studies in animal models of spontaneous and induced HSV-1 reactivation and recurrent disease. Numerous stimuli that induce reactivation in mice and rabbits are described, as well as factors that inhibit viral reactivation from latency. The key features, advantages, and disadvantages of the mouse and rabbit models in relation to the study of ocular HSV-1 are discussed. This paper is pertinent but not intended to be all inclusive. We will give examples of key papers that have reported novel discoveries related to the review topics.

引用

页数：18

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