Acquired platelet defect associated with gabapentin treatment: a case-report

被引：2
作者：
Baglo, Tatiana [1 ]
Pouplard, Claire [1 ,2 ]
Valentin, Jean-Baptiste [1 ]
Guery, Eve-Anne [1 ]
Gruel, Yves [1 ,2 ]
Vayne, Caroline [1 ,2 ]
机构：
[1] Univ Hosp Tours, Dept Haemostasis, Tours, France
[2] Univ Tours, EA GICC 7501, Tours, France
来源：
PLATELETS | 2021年 / 32卷 / 06期
关键词：
Bleeding; gabapentin; platelet defect;
D O I：
10.1080/09537104.2020.1809645
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Gabapentin, a structural analog of gamma-aminobutyric acid, is used to treat peripheral neuropathic pain. Here we report the first case of platelet function disorder associated with gabapentin treatment in a 44-year-old woman without a history of bleeding. She presented with mucocutaneous bleeding approximately 1 month after initiation of gabapentin and platelet function tests showed no aggregation to arachidonic acid and epinephrine, a defective response to ADP and a slightly decreased response to collagen. Gabapentin's imputability was supported by the fact that all platelet functions were normalized 6 days after drug discontinuation, with the simultaneous disappearance of bleedings.
引用
收藏
页码：846 / 849
页数：4
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