The ever-expanding myokinome: discovery challenges and therapeutic implications

被引：199

作者：

Whitham, Martin ^{[1
]}

Febbraio, Mark A. ^{[1
]}

机构：

[1] Garvan Inst Med Res, Diabet & Metab Div, Cellular & Mol Metab Lab, 384 Victoria St, Darlinghurst, NSW 2010, Australia

来源：

NATURE REVIEWS DRUG DISCOVERY | 2016年 / 15卷 / 10期

基金：

英国医学研究理事会;

关键词：

HUMAN SKELETAL-MUSCLE; INTERLEUKIN-6; MESSENGER-RNA; CILIARY NEUROTROPHIC FACTOR; HUMAN PLASMA PROTEOME; WHITE ADIPOSE-TISSUE; PHYSICAL-ACTIVITY; COLORECTAL-CANCER; BROWN ADIPOCYTES; ALPHA PRODUCTION; ENDOCRINE ORGAN;

D O I：

10.1038/nrd.2016.153

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Exercise reduces the risk of a multitude of disorders, from metabolic disease to cancer, but the molecular mechanisms mediating the protective effects of exercise are not completely understood. The realization that skeletal muscle is an endocrine organ capable of secreting proteins termed 'myokines', which participate in tissue crosstalk, provided a critical link in the exercise health paradigm. However, the myokine field is still emerging, and several challenges remain in the discovery and validation of myokines. This Review considers these challenges and highlights some recently identified novel myokines with the potential to be therapeutically exploited in the treatment of metabolic disease and cancer.

引用

收藏

页码：719 / 729

页数：11

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