A novel therapeutic target, GPR43; Where it stands in drug discovery

被引：10

作者：

Kim, Sunhong ^{[1
,2
]}

Kim, You-Me ^{[3
,4
]}

Kwak, Young-Shin ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Chem Biol Res Ctr, Cheongwon 363883, South Korea

[2] Univ Sci & Technol, Dept Biomol Sci, Taejon 305350, South Korea

[3] Pohang Univ Sci & Technol, Dept Life Sci, Pohang 790784, South Korea

[4] Pohang Univ Sci & Technol, Div Integrat Biosci & Biotechnol, Pohang 790784, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2012年 / 35卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

PROTEIN-COUPLED RECEPTOR; CHAIN FATTY-ACIDS; GUT MICROBIOTA; FUNCTIONAL-CHARACTERIZATION; IDENTIFICATION; CANCER; INFLAMMATION; PROPIONATE; ACTIVATION; EXPRESSION;

D O I：

10.1007/s12272-012-0900-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

With growing interest in human microbiome for its implication in metabolic disorders, inflammatory diseases, immune disorders and so forth, understanding the biology at the interface of the gut flora and the host becomes very important for identifying novel therapeutic avenues. GPR43 has been deorphanized and the metabolites of microbiome, such as short-chain fatty acids, serve as its natural ligands. There are numerous reports that GPR43 might be a crucial link to the novel therapies for the unmet medical needs and many drug discovery organizations are making their moves in response.

引用

页码：1505 / 1509

页数：5

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