Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease

被引：63

作者：

Donofrio, Gaetano ^{[1
]}

Ravanetti, Lara ^{[1
]}

Cavirani, Sandro ^{[1
]}

Herath, Shan ^{[2
]}

Capocefalo, Antonio ^{[1
]}

Sheldon, Lain Martin ^{[2
]}

机构：

[1] Univ Parma, Dipartimento Salute Anim, Fac Med Vet, Sez Malattie Infett Anim, I-43100 Parma, Italy

[2] Univ London Royal Vet Coll, Dept Vet Clin Sci, London NW1 0TU, England

来源：

REPRODUCTION | 2008年 / 136卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1530/REP-08-0171

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Experimental infection with the gamma-herpesvirus bovine herpesvirus 4 (BoHV-4) rarely establishes disease, yet BoHV-4 is commonly associated with uterine disease in cattle. Uterine disease involves co-infection with bacteria such as Escherichia coli, which stimulate the production of prostaglandin E-2 (PGE(2)) by endometrial cells. BoHV-4 replication depends on immediate early 2 (IE2) gene transactivation and, in the present study, PGE(2), E. coli or its lipopolysaccharide upregulated the IE2 gene promoter in uterine cells. Bacterial co-infection is important for BoHV-4 uterine disease.

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页码：361 / 366

页数：6

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