Improved antibacterial function of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus

被引：42

作者：

Ghaderkhani, Jalal ^{[1
]}

Yousefimashouf, Rasoul ^{[1
]}

Arabestani, Mohammadreza ^{[1
]}

Roshanaei, Ghodratollah ^{[2
]}

Asl, Sara Soleimani ^{[3
]}

Abbasalipourkabir, Roghayeh ^{[4
]}

机构：

[1] Hamadan Univ Med Sci, Dept Microbiol, Hamadan, Iran

[2] Hamadan Univ Med Sci, Modeling Noncommunicable Dis Res Ctr, Sch Publ Hlth, Dept Biostat & Epidemiol, Hamadan, Iran

[3] Hamadan Univ Med Sci, Endometrium & Endometriosis Res Ctr, Hamadan, Iran

[4] Hamadan Univ Med Sci, Dept Biochem, Hamadan, Iran

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2019年 / 47卷 / 01期

关键词：

Solid lipid nanoparticles; rifampicin; antibacterial activity; Brucella abortus; IN-VITRO; DELIVERY-SYSTEMS; STEARIC-ACID; FORMULATION; CRYSTALLINITY; ENCAPSULATION; STREPTOMYCIN; MACROPHAGES; MELITENSIS; STABILITY;

D O I：

10.1080/21691401.2019.1593858

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The objective of this study was to assess the antibacterial activity of Rifampicin-loaded solid lipid nanoparticles on Brucella abortus 544. Rifampicin-loaded solid lipid nanoparticles were prepared by a modified microemulsion/sonication method and characterized. The results showed the average size about 319.7 nm, PI about 0.20 and zeta potential about 18.4 mv, encapsulation efficacy and drug-loading were equal to 95.78 and 34.2%, respectively, with a spherical shape. Drug release lasted for 5 days. The antibacterial activity was statistically significant with rho < .05 in bacterial and cell culture media compared to free Rifampicin. It can be concluded that solid lipid nanoparticles can be considered as a promising delivery system for improving the antibacterial activity of Rifampicin against Brucella abortus.

引用

页码：1181 / 1193

页数：13

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