Dynamic changes of the epigenetic landscape during cellular differentiation

被引：11

作者：

Dambacher, Silvia ^{[1
,2
]}

de Almeida, Gustavo Pereira ^{[1
,2
]}

Schotta, Gunnar ^{[1
,2
]}

机构：

[1] Univ Munich, D-80336 Munich, Germany

[2] Adolf Butenandt Inst, Munich Ctr Integrated Prot Sci CiPSM, D-80336 Munich, Germany

来源：

EPIGENOMICS | 2013年 / 5卷 / 06期

关键词：

differentiation; DNA methylation; histone modification; lineage commitment; lineage decision; reprogramming; stem cell; RNA-POLYMERASE-II; DNA METHYLATION; CPG ISLANDS; TRANSCRIPTION FACTORS; CHROMATIN-STRUCTURE; COOPERATIVE BINDING; SILENCING PATHWAY; STEM-CELLS; COMPLEX; PLURIPOTENT;

D O I：

10.2217/epi.13.67

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Epigenetic mechanisms are crucial to stabilize cell type-specific gene-expression programs. However, during differentiation, these programs need to be modified - a complex process that requires dynamic but tightly controlled rearrangements in the epigenetic landscape. During recent years, the major epigenetic machineries for gene activation and repression have been extensively characterized. Snapshots of the epigenetic landscape in pluripotent versus differentiated cells have further revealed how chromatin can change during cellular differentiation. Although transcription factors are the key drivers of developmental transitions, it became clear that their function is greatly influenced by the chromatin environment. Better insight into the tight interplay between transcription factor networks and the epigenetic landscape is therefore necessary to improve our understanding of cellular differentiation mechanisms. These systems can then be challenged and modified for the development of regenerative therapies.

引用

页码：701 / 713

页数：13

共 99 条

[71] Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs [J].

Rinn, John L. ;

Kertesz, Michael ;

Wang, Jordon K. ;

Squazzo, Sharon L. ;

Xu, Xiao ;

Brugmann, Samantha A. ;

Goodnough, L. Henry ;

Helms, Jill A. ;

Farnham, Peggy J. ;

Segal, Eran ;

Chang, Howard Y. .

CELL, 2007, 129 (07) :1311-1323

[72] Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells [J].

Ruiz, Sergio ;

Diep, Dinh ;

Gore, Athurva ;

Panopoulos, Athanasia D. ;

Montserrat, Nuria ;

Plongthongkum, Nongluk ;

Kumar, Sachin ;

Fung, Ho-Lim ;

Giorgetti, Alessandra ;

Bilic, Josipa ;

Batchelder, Erika M. ;

Zaehres, Holm ;

Kan, Natalia G. ;

Schoeler, Hans Robert ;

Mercola, Mark ;

Zhang, Kun ;

Izpisua Belmonte, Juan Carlos .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (40) :16196-16201

[73] Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer [J].

Schlesinger, Yeshayahu ;

Straussman, Ravid ;

Keshet, Ilana ;

Farkash, Shlomit ;

Hecht, Merav ;

Zimmerman, Joseph ;

Eden, Eran ;

Yakhini, Zohar ;

Ben-Shushan, Etti ;

Reubinoff, Benjamin E. ;

Bergman, Yehudit ;

Simon, Itamar ;

Cedar, Howard .

NATURE GENETICS, 2007, 39 (02) :232-236

[74] A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin [J].

Schotta, G ;

Lachner, M ;

Sarma, K ;

Ebert, A ;

Sengupta, R ;

Reuter, G ;

Reinberg, D ;

Jenuwein, T .

GENES & DEVELOPMENT, 2004, 18 (11) :1251-1262

[75] A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse [J].

Schotta, Gunnar ;

Sengupta, Roopsha ;

Kubicek, Stefan ;

Malin, Stephen ;

Kauer, Monika ;

Callen, Elsa ;

Celeste, Arkady ;

Pagani, Michaela ;

Opravil, Susanne ;

De La Rosa-Velazquez, Inti A. ;

Espejo, Alexsandra ;

Bedford, Mark T. ;

Nussenzweig, Andre ;

Busslinger, Meinrad ;

Jenuwein, Thomas .

GENES & DEVELOPMENT, 2008, 22 (15) :2048-2061

[76] EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency [J].

Shen, Xiaohua ;

Liu, Yingchun ;

Hsu, Yu-Jung ;

Fujiwara, Yuko ;

Kim, Jonghwan ;

Mao, Xiaohong ;

Yuan, Guo-Cheng ;

Orkin, Stuart H. .

MOLECULAR CELL, 2008, 32 (04) :491-502

[77] The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis [J].

Shilatifard, Ali .

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81, 2012, 81 :65-95

[78] Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome [J].

Soufi, Abdenour ;

Donahue, Greg ;

Zaret, Kenneth S. .

CELL, 2012, 151 (05) :994-1004

[79] DNA-binding factors shape the mouse methylome at distal regulatory regions [J].

Stadler, Michael B. ;

Murr, Rabih ;

Burger, Lukas ;

Ivanek, Robert ;

Lienert, Florian ;

Schoeler, Anne ;

Wirbelauer, Christiane ;

Oakeley, Edward J. ;

Gaidatzis, Dimos ;

Tiwari, Vijay K. ;

Schuebeler, Dirk .

NATURE, 2011, 480 (7378) :490-495

[80] Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells [J].

Stock, Julie K. ;

Giadrossi, Sara ;

Casanova, Miguel ;

Brookes, Emily ;

Vidal, Miguel ;

Koseki, Haruhiko ;

Brockdorff, Neil ;

Fisher, Amanda G. ;

Pombo, Ana .

NATURE CELL BIOLOGY, 2007, 9 (12) :1428-U174

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