Translational boron neutron capture therapy (BNCT) studies for the treatment of tumors in lung

被引：14

作者：

Andrea Trivillin, Veronica ^{[1
,2
]}

Serrano, Ayelen ^{[1
]}

Garabalino, Marcela A. ^{[1
]}

Luis Colombo, Lucas ^{[2
,3
,4
]}

Cesar Pozzi, Emiliano ^{[1
]}

Monti Hughes, Andrea ^{[1
,2
]}

Curotto, Paula M. ^{[1
]}

Ines Thorp, Silvia ^{[1
]}

Farias, Ruben O. ^{[1
]}

Gonzalez, Sara J. ^{[1
,2
]}

Bortolussi, Silva ^{[5
,6
]}

Altieri, Saverio ^{[5
,6
]}

Itoiz, Maria E. ^{[1
,7
]}

Aromando, Romina F. ^{[7
]}

Nigg, David W. ^{[8
]}

Schwint, Amanda E. ^{[1
,2
]}

机构：

[1] Comis Nacl Energia Atom, Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Inst Oncol Angel H Roffo, Area Invest, Buenos Aires, DF, Argentina

[4] Univ Abierta Interamer, Buenos Aires, DF, Argentina

[5] Univ Pavia, Dipartimento Fis Nucl & Teor, Pavia, Italy

[6] Ist Nazl Fis Nucl, Pavia, Italy

[7] Univ Buenos Aires, Fac Odontol, Buenos Aires, DF, Argentina

[8] Idaho Natl Lab, Idaho Falls, ID USA

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 2019年 / 95卷 / 05期

关键词：

Boron neutron capture therapy; BNCT; colon carcinoma; lung metastases; BNCT survival studies; BDIX rats; EXPERIMENTAL-MODEL; ORAL-CANCER; RAT MODEL; IRRADIATION; DIFFUSE; BORONOPHENYLALANINE; METASTASES; EFFICACY; REACTOR; AGENT;

D O I：

10.1080/09553002.2019.1564080

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Purpose: Boron neutron capture therapy (BNCT) combines selective accumulation of B-10 carriers in tumor tissue with subsequent neutron irradiation. BNCT has been proposed for the treatment of multiple, non-resectable, diffuse tumors in lung. The aim of the present study was to evaluate the therapeutic efficacy and toxicity of BNCT in an experimental model of lung metastases of colon carcinoma in BDIX rats and perform complementary survival studies. Materials and methods: We evaluated tumor control and toxicity in lung 2 weeks post-BNCT at 2 dose levels, including 5 experimental groups per dose level: T0 (euthanized pre-treatment), Boronophenylalanine-BNCT (BPA-BNCT), BPA + Sodium decahydrodecaborate-BNCT ((BPA + GB-10)-BNCT), Beam only (BO) and Sham (no treatment, same manipulation). Tumor response was assessed employing macroscopic and microscopic end-points. An additional experiment was performed to evaluate survival and oxygen saturation in blood. Results and conclusions: No dose-limiting signs of short/medium-term toxicity were observed in lung. All end-points revealed statistically significant BNCT-induced tumor control vs Sham at both dose levels. The survival experiment showed a statistically significant 45% increase in post-treatment survival time in the BNCT group (48 days) versus Sham (33 days). These data consistently revealed growth suppression of lung metastases by BNCT with no manifest lung toxicity.

引用

页码：646 / 654

页数：9

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