Synthesis of Vinyl Sulfones via I2-mediated Alkene Sulfonylations with Thiosulfonates

被引:15
作者
Hwang, Sang Joon [1 ]
Shyam, Pranab K. [1 ]
Jang, Hye-Young [1 ]
机构
[1] Ajou Univ, Div Energy Syst Res, Suwon 16499, South Korea
来源
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2018年 / 39卷 / 04期
关键词
Vinyl sulfone; Iodine; Thiosulfonate; Sulfonylation; Alkene; IODINE-MEDIATED SYNTHESIS; CINNAMIC-ACIDS; DECARBOXYLATIVE SULFONYLATION; (E)-VINYL SULFONES; METAL-FREE; ORGANIC-SYNTHESIS; CARBOXYLIC-ACIDS; SULFIDES; FUNCTIONALIZATION; PEPTIDOMIMETICS;
D O I
10.1002/bkcs.11426
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A simple sulfonylation strategy involving I-2 and thiosulfonates, as sulfonyl-group precursors, is reported for the synthesis of vinyl sulfones. Sulfonyl radicals are presumed to be generated from thiosulfonates, which subsequently react with styrene or cinnamic acid derivatives to afford a variety of vinyl sulfones under the described reaction conditions. Detailed conditions, the substrate scope, and mechanistic studies are discussed.
引用
收藏
页码:535 / 539
页数:5
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