Multifunctional Silk-Tropoelastin Biomaterial Systems

被引:12
作者
Ghezzi, Chiara E. [1 ]
Rnjak-Kovacina, Jelena [1 ]
Weiss, Anthony S. [2 ,3 ,4 ]
Kaplan, David L. [1 ]
机构
[1] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA
[2] Univ Sydney, Sch Mol Biosci, Sydney, NSW 2006, Australia
[3] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia
[4] Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
materials science; natural products; polymers; structureactivity relationships; tissue engineering; MECHANICAL-PROPERTIES; EXTRACELLULAR-MATRIX; PROTEIN; COLLAGEN; FIBROIN; ELASTICITY; STEM; INSECTS; COACERVATION; ORGANIZATION;
D O I
10.1002/ijch.201300082
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
New multifunctional, degradable, polymeric biomaterial systems would provide versatile platforms to address cell and tissue needs in both in vitro and in vivo environments. While protein-based composites or alloys are the building blocks of biological organisms, similar systems have not been largely exploited, to date, to generate ad hoc biomaterials able to control and direct biological functions by recapitulating their inherent structural and mechanical complexities. Therefore, we have recently proposed silktropoelastin material platforms that are able to conjugate a mechanically robust and durable protein, silk, to a highly flexible and biologically active protein, tropoelastin. This review focuses on the elucidation of the interactions between silk and tropoelastin to control the structure of the material its properties, and ultimately functions. In addition, an approach is provided for novel material designs to provide tools to control biological outcomes through surface roughness, elasticity, and net charge for neuronal and mesenchymal stem-cell-based tissue engineering.
引用
收藏
页码:777 / 786
页数:10
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