Synthesis and biological activity of 6-substituted 5-acetyl-4,7-dimethoxybenzofuran derivatives

被引：3

作者：

Krawiecka, Mariola ^{[1
]}

Kuran, Bozena ^{[1
]}

Kossakowski, Jerzy ^{[1
]}

Kierzkowska, Marta ^{[2
]}

Mlynarczyk, Grazyna ^{[2
]}

Kazmierczak-Baranska, Julia ^{[3
]}

Krolewska, Karolina ^{[3
]}

Cieslak, Marcin ^{[3
]}

机构：

[1] Med Univ Warsaw, Dept Med Chem, PL-02007 Warsaw, Poland

[2] Med Univ Warsaw, Dept Med Microbiol, PL-02004 Warsaw, Poland

[3] Polish Acad Sci, Dept Bioorgan Chem, Ctr Mol & Macromol Studies, PL-90363 Lodz, Poland

来源：

HETEROCYCLIC COMMUNICATIONS | 2013年 / 19卷 / 04期

关键词：

antifungal activity; antimicrobial activity; benzo[b] furans; cytotoxicity; ANTIBACTERIAL; BENZOFURAN; LIGNANS;

D O I：

10.1515/hc-2013-0081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the search for new antimicrobial and anticancer agents, a series of (aryl/heteroaryl-piperazino-alkyl)substituted derivatives of benzo[b] furans were prepared. All compounds were characterized by H-1 NMR, C-13 NMR, ESI-MS spectra and elemental analyses. Most of the investigated compounds had no antimicrobial activity (MIC > 512 mg/L) except for 2l, 2m and 2o, which showed activity against Candida albicans. None of the tested compounds showed significant anticancer activity in K562 and HeLa cells.

引用

页码：281 / 286

页数：6

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