Fatal atypical O:3 Yersinia pseudotuberculosis infection in cynomolgus macaques

被引：4

作者：

Zao, Chih-Ling ^{[1
]}

Tomanek, Lisa ^{[1
]}

Hurtado-McClure, Graciela ^{[1
]}

Cooke, Anthony ^{[1
]}

Berger, Ron ^{[1
]}

Boulineau, Theresa M. ^{[2
]}

Turner, Oliver C. ^{[2
]}

Covington, Danielle E. ^{[2
]}

机构：

[1] VRL Labs, San Antonio, TX 78229 USA

[2] Novartis Pharmaceut, E Hanover, NJ 07936 USA

来源：

VETERINARY MICROBIOLOGY | 2013年 / 166卷 / 3-4期

关键词：

Yersinia pseudotuberculosis; Cynomolgus macque; O:3; wbyK; PATHOGENICITY; STRAINS;

D O I：

10.1016/j.vetmic.2013.07.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fatal Yersinia pseudotuberculosis infection in cynomolgus macaques was diagnosed based upon pathology, microbiology and PCR for this study. Pathological findings included acute, erosive to ulcerative, necrohemorrhagic enterocolitis. Genotyping by PCR showed an O:3 pattern (gmd-fcl(+), ddhC-prt(+), manB(+), ddhA-B+), but an additional gene, wbyK, was detected. This is the second report to identify wbyK+ O:3 genotype as the cause of fatal yersiniosis. The first case was reported in 2008, and involved farm deer in the U.S. As the frequency of wbyK+ O:3 genotype is found more often in different carriers, O:3 genotype is proposed to be divided into two subtypes: O:3a without wbyK and O:3b with wbyK. Virulence gene analysis showed the presence of inv, ypmC, irp1, ybtP-ybrQ, yadA, yopB, yopH, lcrF, and suggested that this O:3b isolate could be a highly pathogenic strain to cynomolgus macaques. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：681 / 685

页数：5

共 15 条

[1] Use of O-antigen gene cluster-specific PCRs for the identification and O-genotyping of Yersinia pseudotuberculosis and Yersinia pestis [J].