Spike-timing-dependent synaptic modification induced by natural spike trains

被引:617
作者
Froemke, RC [1 ]
Dan, Y [1 ]
机构
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Dept Neurobiol, Berkeley, CA 94720 USA
基金
加拿大健康研究院; 英国惠康基金; 美国国家科学基金会; 英国医学研究理事会;
关键词
D O I
10.1038/416433a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The strength of the connection between two neurons can be modified by activity, in a way that depends on the timing of neuronal firing on either side of the synapse(1-10). This spike-timing-dependent plasticity (STDP) has been studied by systematically varying the intervals between pre- and postsynaptic spikes. Here we studied how STDP operates in the context of more natural spike trains. We found that in visual cortical slices the contribution of each pre-/postsynaptic spike pair to synaptic modification depends not only on the interval between the pair, but also on the timing of preceding spikes. The efficacy of each spike in synaptic modification was suppressed by the preceding spike in the same neuron, occurring within several tens of milliseconds. The direction and magnitude of synaptic modifications induced by spike patterns recorded in vivo in response to natural visual stimuli were well predicted by incorporating the suppressive inter-spike interaction within each neuron. Thus, activity-induced synaptic modification depends not only on the relative spike timing between the neurons, but also on the spiking pattern within each neuron. For natural spike trains, the timing of the first spike in each burst is dominant in synaptic modification.
引用
收藏
页码:433 / 438
页数:6
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