The ratio of serum n-3 to n-6 polyunsaturated fatty acids is associated with diabetes mellitus in patients with prior myocardial infarction: a multicenter cross-sectional study

被引：34

作者：

Takahashi, Masao ^{[1
]}

Ando, Jiro ^{[1
]}

Shimada, Kazunori ^{[2
]}

Nishizaki, Yuji ^{[2
]}

Tani, Shigemasa ^{[3
]}

Ogawa, Takayuki ^{[4
]}

Yamamoto, Masato ^{[5
]}

Nagao, Ken ^{[3
]}

Hirayama, Atsushi ^{[6
]}

Yoshimura, Michihiro ^{[4
]}

Daida, Hiroyuki ^{[2
]}

Nagai, Ryozo ^{[7
]}

Komuro, Issei ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Hongo 7-3-1, Tokyo 1138655, Japan

[2] Juntendo Univ, Grad Sch Med, Dept Cardiol, Bunkyo Ku, Hongo 3-1-3, Tokyo 1138431, Japan

[3] Nihon Univ Hosp, Dept Cardiol, Chiyoda Ku, 1-6 Kanda Surugadai, Tokyo 1018309, Japan

[4] Jikei Univ, Div Cardiol, Dept Internal Med, Sch Med,Minato ku, Nishishinbashi 3-19-18, Tokyo 1058471, Japan

[5] Sempo Takanawa Hosp, Dept Cardiol, Minato Ku, Takanawa 3-10-11, Tokyo 1088606, Japan

[6] Nihon Univ, Div Cardiol, Dept Med, Sch Med,Itabashi ku, 30-1Ohyaguchi Kamichou, Tokyo 1738610, Japan

[7] Jichi Med Univ, Yakushiji 3311-159, Shimotsuke, Tochigi 3290498, Japan

来源：

BMC CARDIOVASCULAR DISORDERS | 2017年 / 17卷

关键词：

Polyunsaturated fatty acids (PUFAs); Prior myocardial infarction (PMI); Diabetes mellitus (DM); High-sensitivity C-reactive protein (hs-CRP); Eicosapentaenoic acid (EPA); Inflammation; Statin; CORONARY-ARTERY-DISEASE; EICOSAPENTAENOIC ACID; CARDIOVASCULAR-DISEASE; NITRIC-OXIDE; RISK; INFLAMMATION; EVENTS; IMPACT; ATHEROSCLEROSIS; PREVENTION;

D O I：

10.1186/s12872-017-0479-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: In prior myocardial infarction (PMI) patients, diabetes mellitus (DM), dyslipidemia, and hypertension increase the risk of secondary cardiovascular events. Although a decreased ratio of serum eicosapentaenoic acid (EPA) to arachidonic acid (AA; EPA/AA) has been shown to significantly correlate with the onset of acute coronary syndrome, the associations between polyunsaturated fatty acid (PUFA) levels and coronary risk factors in PMI patients have not been evaluated thoroughly. This study aimed to assess the associations between PUFAs levels and the risk factors in PMI patients. Methods: We enrolled 1733 patients with known PUFA levels who were treated in five divisions of cardiology in a metropolitan area of Japan, including 303 patients with PMI. EPA/AA and docosahexaenoic acid (DHA) to AA level ratio (DHA/AA) in patients with and without PMI were analyzed according to presence of coronary risk factors. Results: Diabetes patients with PMI had significantly lower EPA/AA and DHA/AA than diabetes patients without PMI (EPA/AA: P < 0.01; DHA/AA: P = 0.003), with no such differences in dyslipidemia and hypertension patients. In DM patients with high high-sensitivity C-reactive protein (hs-CRP) levels (> 0.1 mg/dL), EPA/AA was low in individuals who also had PMI, whereas DHA/AA was not (EPA/AA, with PMI: 0.43 +/- 0.24; without PMI: 0.53 +/- 0.30, P < 0.05). Moreover, patients on statins had significantly lower DHA/AA ratios, whereas the EPA/AA ratio did not depend on statin use. Multiple regression analysis revealed that statin use in DM patients was associated with low DHA/AA but not EPA/AA. Conclusion: PMI patients with DM have low EPA/AA and DHA/AA. EPA/AA and DHA/AA are differently related to hs-CRP level in DM patients with PMI. Statin use can potentially affect DHA/AA but not EPA/AA, and therefore EPA/AA ratio is a better marker of assessment for cardiovascular events.

引用

页数：10

共 40 条

[1] Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: An integrated backscatter intravascular ultrasound study [J].