Phenolic-rich jaboticaba (Plinia jaboticaba (Vell.) Berg) extracts prevent high-fat-sucrose diet-induced obesity in C57BL/6 mice

Obesity has been strongly associated to noncommtmicable chronic diseases, and dietary phenolic compounds with reducing the risk of development of these diseases. Sabara jaboticaba (Plinia jaboticaba) is an Atlantic Forest native fruit, rich in phenolic compounds, such as ellagitannins proanthocyanidins and anthocyanins. We investigated whether phenolic-rich Sabara Jaboticaba extracts (PRJE), with low (LT) or high (HT) tannin concentration can protect C57BL/6 mice from obesity, hyperglycemia, insulin resistance and dyslipidemia induced by high-fat-sucrose diet. Both PRJE, especially the HT extract, prevented the body weight gain while avoiding the white adipose tissues overgrowth. In addition, prevented high fasting blood glucose concentrations and attenuated the hyperinsulinemia. Furthermore, the HT extract prevented high total cholesterol levels. Taken together, our findings confirm that phenolic compounds from Sabara jaboticaba have antiobesity properties and that the tannins play a decisive role in these effects.