Pinning down viral proteins: a new prototype for virus-host cell interaction

被引：9

作者：

Kojima, Yoshitsugu ^{[1
,2
]}

Ryo, Akihide ^{[1
]}

机构：

[1] Yokohama City Univ, Sch Med, Dept Microbiol, Yokohama, Kanagawa 2360004, Japan

[2] Japan Fdn AIDS Prevent, Tokyo, Japan

来源：

FRONTIERS IN MICROBIOLOGY | 2010年 / 1卷

关键词：

phosphorylation; prolyl-isomerization; protein stability; Pin1;

D O I：

10.3389/fmicb.2010.00107

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pin1 is an enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif in its substrate proteins. Recent studies demonstrate that stability of several viral proteins is regulated by phosphorylation-dependent prolyl-isomerization by a host factor Pin1. Pin1 is now positioned as an important modulator of the molecular crosstalk between virus and host cells and could be a unique target for anti-virus therapy. This new type of post-translational modification by Pin1 might be involved in the regulation of other viral proteins.

引用

页数：2

共 8 条

[1] PROTEIN-KINASES AND PHOSPHATASES - THE YIN AND YANG OF PROTEIN-PHOSPHORYLATION AND SIGNALING [J].

HUNTER, T .

CELL, 1995, 80 (02) :225-236

[2] The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation [J].

Jeong, Soo-Jin ;

Ryo, Akihide ;

Yamamoto, Naoki .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 381 (02) :294-299

[3] The prolyl isomerase PIN 1: a pivotal new twist in phosphorylation signalling and disease [J].

Lu, Kun Ping ;

Zhou, Xiao Zhen .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (11) :904-916

[4] Prolyl cis-trans isomerization as a molecular timer [J].

Lu, Kun Ping ;

Finn, Greg ;

Lee, Tae Ho ;

Nicholson, Linda K. .

NATURE CHEMICAL BIOLOGY, 2007, 3 (10) :619-629

[5] Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes [J].

Manganaro, Lara ;

Lusic, Marina ;

Gutierrez, Maria Ines ;

Cereseto, Anna ;

Del Sal, Giannino ;

Giacca, Mauro .

NATURE MEDICINE, 2010, 16 (03) :329-U128

[6] Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis [J].

Pang, Roberta ;

Lee, Terence K. W. ;

Poon, Ronnie T. P. ;

Fan, Sheung T. ;

Wong, Kam B. ;

Kwong, Yok-Lam ;

Tse, Eric .

GASTROENTEROLOGY, 2007, 132 (03) :1088-1103

[7] Peptidylproline cis-trans-Isomerase Pin1 Interacts with Human T-Cell Leukemia Virus Type 1 Tax and Modulates Its Activation of NF-κB [J].

Peloponese, Jean-Marie, Jr. ;

Yasunaga, Junichiro ;

Kinjo, Takao ;

Watashi, Koichi ;

Jeang, Kuan-Teh .

JOURNAL OF VIROLOGY, 2009, 83 (07) :3238-3248

[8] Prolyl isomerase Pin1: a catalyst for oncogenesis and a potential therapeutic target in cancer [J].

Ryo, A ;

Liou, YC ;

Lu, KP ;

Wulf, G .

JOURNAL OF CELL SCIENCE, 2003, 116 (05) :773-783

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