Protective role of Nigella sativa in chemotherapy-induced alopecia

被引：0

作者：

Saleem, Uzma ^{[1
]}

Sabir, Shakila ^{[1
]}

Ahmad, Bashir ^{[2
]}

机构：

[1] Govt Coll Univ Faisalabad, Fac Pharmaceut Sci, Faisalabad, Pakistan

[2] Riphah Int Univ, Riphah Inst Pharmaceut Sci, Lahore Campus, Lahore, Pakistan

来源：

BANGLADESH JOURNAL OF PHARMACOLOGY | 2017年 / 12卷 / 04期

关键词：

ANDROGENETIC ALOPECIA; HAIR-GROWTH; INHIBITOR; CANCER; 5-ALPHA-REDUCTASE; WOMEN; DRUG; MICE;

D O I：

10.3329/bjp.v12i4.33552

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chemotherapy-induced alopecia affects the pathological as well as the psychological aspects of the cancer patient. In the present study, the protective role of Nigella sativa was evaluated in both adult and newborn albino rats. The anagen phase was first induced. N. sativa oil, N. sativa decoction (5%, 10% and 15%) and minoxidil lotion (standard) were applied daily to the rats two days after the depilation. During the anagen VI phase of the hair follicles, alopecia was induced by giving cyclophosphamide 125 mg/kg, ip to the adult rat and 50 mg/kg to the newborn rats. Cyclophosphamide-induced the alopecia to the whole depilated area of skin in adult rat while alopecia totalis was observed in the newborn rat disease control group. N. sativa oil, N. sativa decoction (5%) showed a significant protective effect against cyclophos-phamide-induced alopecia. In conclusion, it is evident that N. sativa provides significant protection against chemotherapy-induced alopecia.

引用

页码：455 / 462

页数：8

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