Integrating rnRNA processing with transcription

被引：837
作者：
Proudfoot, NJ [1 ]
Furger, A [1 ]
Dye, MJ [1 ]
机构：
[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
来源：
CELL | 2002年 / 108卷 / 04期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
D O I：
10.1016/S0092-8674(02)00617-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination.
引用
收藏
页码：501 / 512
页数：12
相关论文
共 86 条
[1]  
Aranda A, 1999, MOL CELL BIOL, V19, P1251
[2]   Transcriptional termination factors for RNA polymerase II in yeast [J].
Aranda, A ;
Proudfoot, N .
MOLECULAR CELL, 2001, 7 (05) :1003-1011
[3]   Cleavage/polyadenylation factor IA associates with the carboxyl-terminal domain of RNA polymerase II in Saccharomyces cerevisiae [J].
Barillà, D ;
Lee, BA ;
Proudfoot, NJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (02) :445-450
[4]   Transcriptional termination in the Balbiani ring 1 gene is closely coupled to 3′-end formation and excision of the 3′-terminal intron [J].
Baurén, G ;
Belikov, S ;
Wieslander, L .
GENES & DEVELOPMENT, 1998, 12 (17) :2759-2769
[5]   DEGRADATION OF MESSENGER-RNA IN EUKARYOTES [J].
BEELMAN, CA ;
PARKER, R .
CELL, 1995, 81 (02) :179-183
[6]   SPLICE SITE SELECTION, RATE OF SPLICING, AND ALTERNATIVE SPLICING ON NASCENT TRANSCRIPTS [J].
BEYER, AL ;
OSHEIM, YN .
GENES & DEVELOPMENT, 1988, 2 (06) :754-765
[7]   Transcriptional termination signals for RNA polymerase II in fission yeast [J].
Birse, CE ;
Lee, BA ;
Hansen, K ;
Proudfoot, NJ .
EMBO JOURNAL, 1997, 16 (12) :3633-3643
[8]   Coupling termination of transcription to messenger RNA maturation in yeast [J].
Birse, CE ;
Minvielle-Sebastia, L ;
Lee, BA ;
Keller, W ;
Proudfoot, NJ .
SCIENCE, 1998, 280 (5361) :298-301
[9]  
Burge CB, 1999, RNA WORLD, P525
[10]   Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination [J].
Calvo, O ;
Manley, JL .
MOLECULAR CELL, 2001, 7 (05) :1013-1023
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