A chronic ethanol-feeding study in rhesus monkeys

被引：3

作者：

Pawlosky, RJ ^{[1
]}

Salem, N

机构：

[1] USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA

[2] NIAAA, NIH, Rockville, MD 20852 USA

来源：

LIPIDS | 1999年 / 34卷

关键词：

D O I：

10.1007/BF02562261

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study describes the effect of chronic ethanol-feeding in rhesus monkeys. Animals which were maintained on a diet containing 18:2n-6 and 18:3n-3 as 1.4 and 0.08% of the calories, respectively, and consumed alcohol (mean 2.6 g kg(-1) d(-1)) had decreased amounts of 20:4n-6 and 22:6n-3 in their livers and plasma lipids compared with controls. Alcohol consumption did not appear to effect the absorption of H-2(5)-18:2n-6 and 18:3n-3 esters into the blood following an oral dose. There was an increase in H-2(5) enrichment in plasma 20:4n-6 and 22:6n-3, indicating that alcohol may have increased production of these fatty acids. There was a greater concentration of 4-hydroxynonenal in the plasma of alcohol-exposed monkeys compared to controls.

引用

页码：S131 / S132

页数：2