Current State and Future Challenges of Mass Spectrometry Imaging for Clinical Research

被引：89

作者：

Addie, Ruben D. ^{[1
,2
]}

Balluff, Benjamin ^{[1
]}

Bovee, Judith V. M. G. ^{[2
]}

Morreau, Hans ^{[2
]}

McDonnell, Liam A. ^{[1
,3
]}

机构：

[1] Leiden Univ, Ctr Prote & Metabol, Med Ctr, Leiden, Netherlands

[2] Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands

[3] Fdn Pisana Sci ONLUS, Pisa, Italy

来源：

ANALYTICAL CHEMISTRY | 2015年 / 87卷 / 13期

关键词：

ELECTROSPRAY-IONIZATION; PROTEIN EXPRESSION; HETEROGENEITY; RESOLUTION; SAMPLES;

D O I：

10.1021/acs.analchem.5b00416

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The ability of mass spectrometry imaging (MSI) to localize panels of biomolecules in tissues, without prior knowledge of their presence and in a label-free manner, has led to a rapid and substantial impact in clinical and pharmacological research, uncovering biomolecular changes associated with disease and providing low cost imaging of pharmaceuticals. This Feature article will give an introduction to the capabilities and role of MSI in the clinical analysis of patient tissues and discusses those improvements that are necessary for the progression of MSI toward routine clinical application.

引用

页码：6426 / 6433

页数：8

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