FRESH FROZEN PLASMA FOR PROGRESSIVE AND REFRACTORY ANGIOTENSIN-CONVERTING ENZYME INHIBITOR-INDUCED ANGIOEDEMA

被引：38

作者：

Hassen, Getaw Worku ^{[1
]}

Kalantari, Hossein ^{[1
]}

Parraga, Monica ^{[1
]}

Chirurgi, Roger ^{[1
]}

Meletiche, Carlos ^{[1
]}

Chan, Christopher ^{[1
]}

Ciarlo, Jacque ^{[1
]}

Gazi, Farhad ^{[1
]}

Lobaito, Christopher ^{[1
]}

Tadayon, Siamak ^{[1
]}

Yemane, Selamawit ^{[1
]}

Velez, Carolina ^{[1
]}

机构：

[1] New York Med Coll, Metropolitan Hosp Ctr, Dept Emergency Med, New York, NY 10029 USA

来源：

JOURNAL OF EMERGENCY MEDICINE | 2013年 / 44卷 / 04期

关键词：

ACEI; angioedema; bradykinin; FFP; DIPEPTIDYL PEPTIDASE-IV; II RECEPTOR ANTAGONISTS; HEREDITARY ANGIOEDEMA; ACE-INHIBITOR; C1; INHIBITOR; C1-INHIBITOR DEFICIENCY; MEDIATED ANGIOEDEMA; INCREASED RISK; BRADYKININ; EDEMA;

D O I：

10.1016/j.jemermed.2012.07.055

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Background: Angioedema secondary to angiotensin-converting enzyme inhibitors (ACEI) is a commonly encountered problem in the Emergency Department (ED). The treatment of ACEI-induced edema with conventional methods such as epinephrine, steroids, and antihistamines is usually not effective. There is limited experience using bradykinin receptor blockers and fresh frozen plasma (FFP) as a treatment modality for ACEI-induced angioedema. Objective: To emphasize alternative treatment option for ACEI-induced angioedema in the ED. Case Reports: We report a case series of progressive and refractory presumed ACEI-induced angioedema that all improved in temporal association with administration of FFP, with a brief review of the literature. Conclusion: There was a temporal association between the administration of FFP and improvement in angioedema in seven cases of presumed ACEI-induced angioedema that were refractory to antihistamines, corticosteroids, and epinephrine. Published by Elsevier Inc.

引用

页码：764 / 772

页数：9

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