Regulation of Channel Function Due to Coupling with a Lipid Bilayer

被引：14
作者：
Ashrafuzzaman, Md [1 ,2 ]
Tuszynski, J. [1 ,3 ]
机构：
[1] Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB T6G 1Z2, Canada
[2] Cornell Univ, Weill Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA
[3] Univ Alberta, Dept Phys, Edmonton, AB T6G 2E1, Canada
来源：
JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE | 2012年 / 9卷 / 04期
基金：
加拿大自然科学与工程研究理事会;
关键词：
Lipid Bilayer; Ion Channel; Membrane Protein; Screened Coulomb Interaction; X-RAY-DIFFRACTION; GRAMICIDIN CHANNEL; PHOSPHOLIPID-BILAYER; INTRINSIC CURVATURE; MEMBRANE-PROTEIN; DEFORMATIONS; ALAMETHICIN; ENERGETICS; POLYELECTROLYTES; CONDUCTANCE;
D O I：
10.1166/jctn.2012.2062
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Regulation of membrane protein functions due to hydrophobic coupling with a lipid bilayer is investigated. An energy formula based on the screened Coulomb interaction approximation has been developed between lipid bilayer and integral ion channels with different structures. We find that the hydrophobic bilayer thickness channel length mismatch induces channel destabilization exponentially while negative lipid curvature linearly. Experimental parameters related to channel dynamics are consistent with theoretical predictions. This study provides a new insight that provides better understanding of the underlying mechanisms of membrane protein functions in biological systems.
引用
收藏
页码：564 / 570
页数：7
相关论文
共 40 条
[1]   Energetics of ion conduction through the gramicidin channel [J].
Allen, TW ;
Andersen, OS ;
Roux, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (01) :117-122
[2]   Bilayer thickness and membrane protein function: An energetic perspective [J].
Andersen, Olaf S. ;
Koeppe, Roger E., II .
ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2007, 36 :107-130
[3]  
Ashrafuzzaman M., 2004, THESIS U NEUCHATEL, P85
[4]   Manipulating lipid bilayer material properties using biologically active amphipathic molecules [J].
Ashrafuzzaman, Md ;
Lampson, M. A. ;
Greathouse, D. V. ;
Koeppe, R. E., II ;
Andersen, O. S. .
JOURNAL OF PHYSICS-CONDENSED MATTER, 2006, 18 (28) :S1235-S1255
[5]   The antimicrobial peptide gramicidin S permeabilizes phospholipid bilayer membranes without forming discrete ion channels [J].
Ashrafuzzaman, Md. ;
Andersen, O. S. ;
McElhaney, R. N. .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2008, 1778 (12) :2814-2822
[6]   ELECTRICAL CAPACITY OF BLACK LIPID FILMS AND OF LIPID BILAYERS MADE FROM MONOLAYERS [J].
BENZ, R ;
FROHLICH, O ;
LAUGER, P ;
MONTAL, M .
BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 394 (03) :323-334
[7]   STATISTICAL-ANALYSIS OF ALAMETHICIN CHANNELS IN BLACK LIPID-MEMBRANES [J].
BOHEIM, G .
JOURNAL OF MEMBRANE BIOLOGY, 1974, 19 (03) :277-303
[8]  
Daune M., 1999, Molecular biophysics: structures in motion
[9]   Comment on "Cluster Formation of Transmembrane Proteins Due to Hydrophobic Mismatching" [J].
de Meyer, Frederick ;
Smit, Berend .
PHYSICAL REVIEW LETTERS, 2009, 102 (21)
[10]   ENERGETICS OF HETERODIMER FORMATION AMONG GRAMICIDIN ANALOGS WITH AN NH2-TERMINAL ADDITION OR DELETION - CONSEQUENCES OF MISSING A RESIDUE AT THE JOIN IN THE CHANNEL [J].
DURKIN, JT ;
PROVIDENCE, LL ;
KOEPPE, RE ;
ANDERSEN, OS .
JOURNAL OF MOLECULAR BIOLOGY, 1993, 231 (04) :1102-1121
1234