Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells

被引：104

作者：

Zhou, Cheng-Fu ^{[1
]}

Li, Xue-Bing ^{[2
]}

Sun, Heng ^{[2
]}

Zhang, Bo ^{[1
]}

Han, Yu-Song ^{[1
]}

Jiang, Yi ^{[1
]}

Zhuang, Qiu-Lin ^{[1
]}

Fang, Jing ^{[2
]}

Wu, Guo-Hao ^{[1
]}

机构：

[1] Fudan Univ, Sch Med, Zhongshan Hosp, Dept Surg, Shanghai 200032, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China

来源：

IUBMB LIFE | 2012年 / 64卷 / 09期

关键词：

colorectal cancer; cell proliferation; cellular glucose metabolism; migration; protein function; protein expression; pyruvate kinase; HUMAN-PAPILLOMAVIRUS TYPE-16; TUMOR-GROWTH; EXPRESSION; PKM2; TRANSFORMATION; METASTASIS; INVASION; PREDICT;

D O I：

10.1002/iub.1066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pyruvate kinase type M2 (PKM2) has been reported to be involved in aerobic glycolysis and cell growth in various tumors. However, the expression pattern of PKM2 in colorectal cancer (CRC) and the correlation between PKM2 expression and CRC remains unclear. The aim of this study is to investigate PKM2 expression and its possible role in CRC. We found that expression of PKM2 was increased in CRC and the increased PKM2 expression was associated with later stage and lymph metastasis of the tumors. Knockdown of PKM2 suppressed the aerobic glycolysis and decreased lactate production of colon cancer RKO cells. Knockdown of PKM2 repressed proliferation and migration of the cells. Inhibition of PKM2 suppressed xenograft tumor growth of RKO cells in vivo. These results suggest that the expression of PKM2 plays a critical role in development of CRC, and it may provide a growth advantage for colon cancer cells. Thus, PKM2 might be a potential therapeutic target for CRC. (c) 2012 IUBMB Life, 64(9): 775782, 2012

引用

页码：775 / 782

页数：8

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