Quantitative analysis of neovascular permeability in glioma by dynamic contrast-enhanced MR imaging

被引：55

作者：

Jia, Zhongzheng ^{[1
]}

Geng, Daoying ^{[1
]}

Xie, Tianwen ^{[2
]}

Zhang, Jiaoyan ^{[3
]}

Liu, Ying ^{[4
]}

机构：

[1] Fudan Univ, Dept Radiol, Huashan Hosp, Shanghai 200040, Peoples R China

[2] Siemens Ltd, Applicat Specialist Team, Shanghai, Peoples R China

[3] Fudan Univ, Sch Publ Hlth, Dept Biostat, Shanghai 200433, Peoples R China

[4] Fudan Univ, Shanghai Med Coll, Dept Pathol, Shanghai 200433, Peoples R China

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2012年 / 19卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Dynamic contrast-enhanced; Extravascular extracellular space; Glioma; Grading; Neovascular permeability; Volume transfer constant; CEREBRAL BLOOD-VOLUME; MICROVASCULAR PERMEABILITY; HIGH-GRADE; K-TRANS; PERFUSION; TUMORS; DIFFERENTIATION; CANCER;

D O I：

10.1016/j.jocn.2011.08.030

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study was designed to quantitatively analyse neovascular permeability in glioma by dynamic contrast-enhanced MRI (DCE-MRI). Forty-four patients with glioma were included in this study. The highest value of volume transfer constant (K-trans) and volume of extravascular extracellular space per unit volume of tissue (lie) were obtained and the differences in K-trans and V-e between low-grade glioma (LGG) and high-grade glioma (HGG) were analyzed. The correlations between K-trans. Ve and glioma grade were performed. Receiver operating characteristic (ROC) curve analyses were conducted. The values of K-trans and V-e of LGG were significantly lower than those of HGG. The correlation analysis demonstrated statistically significant relationships between K-trans and glioma grade, between V-e and glioma grade, and between K-trans and V-e. The ROC curve analyses of K-trans (0.035/min) and V-e (0.130) for differentiating LGG from HGG were statistically significant. Thus, DCE-MRI can be used to estimate neovascular permeability and for pre-operative grading of glioma. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：820 / 823

页数：4

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