Genetic and phenotypic influences on copulatory plug survival in mice

被引:26
作者
Mangels, R. [1 ]
Young, B. [1 ]
Keeble, S. [1 ,2 ]
Ardekani, R. [3 ]
Meslin, C. [4 ]
Ferreira, Z. [4 ]
Clark, N. L. [4 ]
Good, J. M. [2 ]
Dean, M. D. [1 ]
机构
[1] Univ So Calif, Mol & Computat Biol, Los Angeles, CA 90089 USA
[2] Univ Montana, Div Biol Sci, Missoula, MT 59812 USA
[3] Univ So Calif, Translat Imaging Ctr, Los Angeles, CA 90089 USA
[4] Univ Pittsburgh, Dept Computat & Syst Biol, Pittsburgh, PA USA
基金
美国国家科学基金会;
关键词
SPERM COMPETITION; SEMINAL FLUID; SEXUAL SELECTION; HOUSE MICE; REPRODUCTIVE PROTEINS; POPULATION-GENETICS; SERINE PROTEASES; VAGINAL PLUG; MATE CHOICE; EVOLUTION;
D O I
10.1038/hdy.2015.50
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
Across a diversity of animals, male seminal fluid coagulates upon ejaculation to form a hardened structure known as a copulatory plug. Previous studies suggest that copulatory plugs evolved as a mechanism for males to impede remating by females, but detailed investigations into the time course over which plugs survive in the female's reproductive tract are lacking. Here, we cross males from eight inbred strains to females from two inbred strains of house mice (Mus musculus domesticus). Plug survival was significantly affected by male genotype. Against intuition, plug survival time was negatively correlated with plug size: long-lasting plugs were small and relatively more susceptible to proteolysis. Plug size was associated with divergence in major protein composition of seminal vesicle fluid, suggesting that changes in gene expression may play an important role in plug dynamics. In contrast, we found no correlation to genetic variation in the protein-coding regions of five genes thought to be important in copulatory plug formation (Tgm4, Svs1, Svs2, Svs4 and Svs5). Our study demonstrates a complex relationship between copulatory plug characteristics and survival. We discuss several models to explain unexpected variation in plug phenotypes.
引用
收藏
页码:496 / 502
页数:7
相关论文
共 97 条
[1]  
Andersson Malte, 1994
[2]  
Arnqvist Goran, 2005, pUnpaginated
[3]  
Asdell SA., 1946, Patterns of Mammalian Reproduction
[4]   Demonstration of a quantitative relation between stimulus and response in pseudopregnancy in the rat [J].
Ball, J .
AMERICAN JOURNAL OF PHYSIOLOGY, 1934, 107 (03) :698-703
[5]   COPULATORY PLUGS AND PATERNITY ASSURANCE IN THE NEMATODE CAENORHABDITIS-ELEGANS [J].
BARKER, DM .
ANIMAL BEHAVIOUR, 1994, 48 (01) :147-156
[6]   Fluctuating selection: the perpetual renewal of adaptation in variable environments [J].
Bell, Graham .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2010, 365 (1537) :87-97
[7]   Postmating Sexual Selection Favors Males That Sire Offspring with Low Fitness [J].
Bilde, Trine ;
Foged, Anne ;
Schilling, Nadia ;
Arnqvist, Goran .
SCIENCE, 2009, 324 (5935) :1705-1706
[8]   Postcopulatory sexual selection [J].
Birkhead, TR ;
Pizzari, T .
NATURE REVIEWS GENETICS, 2002, 3 (04) :262-273
[9]  
BLANDAU RJ, 1945, ANAT REC, V91, P266
[10]   ON THE FACTORS INVOLVED IN SPERM TRANSPORT THROUGH THE CERVIX UTERI OF THE ALBINO RAT [J].
BLANDAU, RJ .
AMERICAN JOURNAL OF ANATOMY, 1945, 77 (02) :253-272