Azaphilone and Diphenyl Ether Derivatives from a Gorgonian-Derived Strain of the Fungus Penicillium pinophilum

被引：57

作者：

Zhao, Dong-Lin ^{[1
]}

Shao, Chang-Lun ^{[1
]}

Zhang, Qiang ^{[3
]}

Wang, Kai-Ling ^{[1
]}

Guan, Fei-Fei ^{[1
]}

Shi, Ting ^{[1
]}

Wang, Chang-Yun ^{[1
,2
]}

机构：

[1] Ocean Univ Qingdao, Sch Med & Pharm, Minist Educ China, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Ocean Univ Qingdao, Inst Evolut & Marine Biodivers, Qingdao 266003, Peoples R China

[3] Northwest A&F Univ, Coll Sci, Yangling 712100, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 09期

基金：

中国国家自然科学基金;

关键词：

ABSOLUTE-CONFIGURATIONS;

D O I：

10.1021/acs.jnatprod.5b00575

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new azaphilone derivatives, pinophilins D-F (1-3), and one new diphenyl ether derivative, hydroxypenicillide (10), together with nine known compounds (4-9, 11-13), were isolated from the gorgonian-derived fungus Penicillium pinophilum XS-20090E18. Their structures including absolute configurations were determined by spectroscopic data, chemical conversions, the ECD exciton chirality method, and ECD calculations. Compounds 10-13 exhibited inhibitory activity against the larval settlement of the barnacle Balanus amp hitrite at nontoxic concentrations. Compounds 10 and 11 showed cytotoxicity against Hep-2, RD, and HeLa cell lines.

引用

页码：2310 / 2314

页数：5

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