Rh(III)-catalyzed C-H activation/[4+3] cycloaddition of benzamides and vinylcarbenoids: facile synthesis of azepinones

被引：235
作者：
Cui, Sunliang [1 ]
Zhang, Yan
Wang, Dahai
Wu, Qifan
机构：
[1] Zhejiang Univ, Inst Mat Med, Hangzhou 310058, Zhejiang, Peoples R China
来源：
CHEMICAL SCIENCE | 2013年 / 4卷 / 10期
关键词：
N BOND FORMATION; CATALYZED OXIDATIVE CYCLOADDITION; ONE-POT SYNTHESIS; BENZOIC-ACIDS; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; INTRAMOLECULAR 4+2; INTERNAL ALKYNES; RHODIUM; ANNULATION;
D O I：
10.1039/c3sc51777b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Vinylcarbenoids are used as three-carbon components in Rh(III)-catalyzed C-H activation/[4 + 3] cycloaddition with benzamides to access azepinones. This transformation makes a feature of simple starting materials, mild reaction conditions and high efficiency. A kinetic isotope effect study was conducted and a plausible mechanism is proposed.
引用
收藏
页码：3912 / 3916
页数：5
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