Rh(III)-catalyzed C-H activation/[4+3] cycloaddition of benzamides and vinylcarbenoids: facile synthesis of azepinones

被引：237

作者：

Cui, Sunliang ^{[1
]}

Zhang, Yan

Wang, Dahai

Wu, Qifan

机构：

[1] Zhejiang Univ, Inst Mat Med, Hangzhou 310058, Zhejiang, Peoples R China

来源：

CHEMICAL SCIENCE | 2013年 / 4卷 / 10期

关键词：

N BOND FORMATION; CATALYZED OXIDATIVE CYCLOADDITION; ONE-POT SYNTHESIS; BENZOIC-ACIDS; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; INTRAMOLECULAR 4+2; INTERNAL ALKYNES; RHODIUM; ANNULATION;

D O I：

10.1039/c3sc51777b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Vinylcarbenoids are used as three-carbon components in Rh(III)-catalyzed C-H activation/[4 + 3] cycloaddition with benzamides to access azepinones. This transformation makes a feature of simple starting materials, mild reaction conditions and high efficiency. A kinetic isotope effect study was conducted and a plausible mechanism is proposed.

引用

页码：3912 / 3916

页数：5

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