DOES INTRAVENOUS VITAMIN C IMPROVE MORTALITY IN PATIENTS WITH SEVERE SEPSIS?

被引：1

作者：

Sheikh, Mohammed ^{[1
]}

Horner, Daniel ^{[1
]}

机构：

[1] Salford Royal NHS Fdn Trust, Salford, Lancs, England

来源：

EMERGENCY MEDICINE JOURNAL | 2018年 / 35卷 / 04期

关键词：

ASCORBIC-ACID; SEPTIC SHOCK;

D O I：

10.1136/emermed-2018-207608.3

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

A shortcut review was carried out to establish whether the use of intravenous vitamin C can reduce mortality or morbidity in patients diagnosed in the early phases of severe sepsis. Three directly relevant papers were found using the reported search strategy. The author, date and country of publication; patient group studied; study type; relevant outcomes; results and study weaknesses of the best papers are tabulated. It is concluded that there is insufficient high-quality research to justify the routine use of vitamin C in severe sepsis. Further multicentre, double-blinded randomised controlled trials are required in order to establish the role of vitamin C in sepsis.

引用

页码：272 / +

页数：3

共 8 条

[1] Oxalate Nephropathy After Continuous Infusion of High-Dose Vitamin C as an Adjunct to Burn Resuscitation [J].

Buehner, Michelle ;

Pamplin, Jeremy ;

Studer, Lynette ;

Hughes, Rhome L. ;

King, Booker T. ;

Graybill, John C. ;

Chung, Kevin K. .

JOURNAL OF BURN CARE & RESEARCH, 2016, 37 (04) :E374-E379

[2]

England N, 2015, IMPR OUTC PAT SEPS

[3] Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis [J].

Fowler, Alpha A., III ;

Syed, Aamer A. ;

Knowlson, Shelley ;

Sculthorpe, Robin ;

Farthing, Don ;

DeWilde, Christine ;

Farthing, Christine A. ;

Larus, Terri L. ;

Martin, Erika ;

Brophy, Donald F. ;

Gupta, Seema ;

Fisher, Bernard J. ;

Natarajan, Ramesh .

JOURNAL OF TRANSLATIONAL MEDICINE, 2014, 12

[4] Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study [J].

Marik, Paul E. ;

Khangoora, Vikramjit ;

Rivera, Racquel ;

Hooper, Michael H. ;

Catravas, John .

CHEST, 2017, 151 (06) :1229-1238

[5] Sepsis-associated mortality in England: an analysis of multiple cause of death data from 2001 to 2010 [J].

McPherson, Duncan ;

Griffiths, Clare ;

Williams, Matthew ;

Baker, Allan ;

Klodawski, Ed ;

Jacobson, Bobbie ;

Donaldson, Liam .

BMJ OPEN, 2013, 3 (08)

[6] Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration - A randomized, prospective study [J].

Tanaka, H ;

Matsuda, T ;

Miyagantani, Y ;

Yukioka, T ;

Matsuda, H ;

Shimazaki, S .

ARCHIVES OF SURGERY, 2000, 135 (03) :326-331

[7] Mechanism of action of vitamin C in sepsis: Ascorbate modulates redox signaling in endothelium [J].

Wilson, John X. .

BIOFACTORS, 2009, 35 (01) :5-13

[8] Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock [J].

Zabet, Mohadeseh Hosseini ;

Mohammadi, Mostafa ;

Ramezani, Masoud ;

Khalili, Hossein .

JOURNAL OF RESEARCH IN PHARMACY PRACTICE, 2016, 5 (02) :94-100

← 1 →