Indium(III) Chloride-Catalyzed Isocyanide Insertion Reaction to Construct Complex Spirooxindole

被引：73

作者：

Tian, Yaming ^{[1
]}

Tian, Lumin ^{[1
]}

He, Xiang ^{[1
]}

Li, Chunju ^{[1
]}

Jia, Xueshun ^{[1
,2
]}

Li, Jian ^{[1
]}

机构：

[1] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 19期

基金：

中国国家自然科学基金;

关键词：

ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; C-O BOND; MULTICOMPONENT REACTIONS; SPIROCYCLIC OXINDOLES; MOLECULAR COMPLEXITY; 3-COMPONENT REACTION; MULTIPLE INSERTION; CONCISE SYNTHESIS; LEWIS ACID; CYCLOADDITION;

D O I：

10.1021/acs.orglett.5b02432

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unusual multiple isocyanide insertion reaction with methyleneindolinone using indium(III) chloride as the catalyst has been disclosed. This strategy allows for the rapid construction of structurally complex spirooxindole in an efficient manner. The present protocol features mild conditions, atom economy, and broad substrate scope.

引用

页码：4874 / 4877

页数：4

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