Enantioselective, Catalytic Trichloromethylation through Visible-Light-Activated Photoredox Catalysis with a Chiral Iridium Complex

被引：163

作者：

Huo, Haohua ^{[1
]}

Wang, Chuanyong ^{[1
]}

Harms, Klaus ^{[1
]}

Meggers, Eric ^{[1
,2
]}

机构：

[1] Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany

[2] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 30期

关键词：

RADICAL HALOALKYLATION; ELECTRON-TRANSFER; PHOTOCATALYSIS; ALKYLATION; TRIFLUOROMETHYLATION; TRANSFORMATIONS; ALDEHYDES; DYSIDIN; ACID;

D O I：

10.1021/jacs.5b06010

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective, catalytic trichloromethylation of 2-acyl imidazoles and 2-acylpyridines is reported. Several products are formed with enantiomeric excess of >= 99%. In this system, a chiral iridium complex serves a dual function, as a catalytically active chiral Lewis acid and simultaneously as a precursor for an in situ assembled visible-light-triggered photoredox catalyst.

引用

页码：9551 / 9554

页数：4

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