Enantioselective, Catalytic Trichloromethylation through Visible-Light-Activated Photoredox Catalysis with a Chiral Iridium Complex

被引：161
作者：
Huo, Haohua [1 ]
Wang, Chuanyong [1 ]
Harms, Klaus [1 ]
Meggers, Eric [1 ,2 ]
机构：
[1] Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany
[2] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 30期
关键词：
RADICAL HALOALKYLATION; ELECTRON-TRANSFER; PHOTOCATALYSIS; ALKYLATION; TRIFLUOROMETHYLATION; TRANSFORMATIONS; ALDEHYDES; DYSIDIN; ACID;
D O I：
10.1021/jacs.5b06010
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An enantioselective, catalytic trichloromethylation of 2-acyl imidazoles and 2-acylpyridines is reported. Several products are formed with enantiomeric excess of >= 99%. In this system, a chiral iridium complex serves a dual function, as a catalytically active chiral Lewis acid and simultaneously as a precursor for an in situ assembled visible-light-triggered photoredox catalyst.
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收藏
页码：9551 / 9554
页数：4
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