First screening of Aedes albopictus immunogenic salivary proteins

被引：20

作者：

Doucoure, S. ^{[1
,2
]}

Cornelie, S. ^{[1
,2
]}

Patramool, S. ^{[1
,2
]}

Mouchet, F. ^{[1
,2
]}

Demettre, E. ^{[3
]}

Seveno, M. ^{[3
]}

Dehecq, J. S. ^{[5
]}

Rutee, H. ^{[5
]}

Herve, J. P. ^{[1
,2
]}

Favier, F. ^{[4
]}

Misse, D. ^{[1
,2
]}

Gasque, P. ^{[6
]}

Remoue, F. ^{[1
,2
]}

机构：

[1] Univ Montpellier I, MIVEGEC Malad Infect & Vecteurs Ecol Genet Evolut, Montpellier, France

[2] Univ Montpellier 2, Montpellier, France

[3] Inst Genom Fonctionnelle, Montpellier, France

[4] Ctr Invest Clin, Epidemiol Clin, St Pierre, Reunion, France

[5] Agence Reg Sante Ocean Indien, St Denis, Reunion, France

[6] Univ Reunion, Grp Rech Immunopathol & Malad Infect, La Reunion, France

来源：

INSECT MOLECULAR BIOLOGY | 2013年 / 22卷 / 04期

关键词：

Ae; albopictus; saliva; immunogenic; exposure; biomarker; ANTIBODY-RESPONSE; LUTZOMYIA-LONGIPALPIS; ANOPHELES-GAMBIAE; EPIDEMIOLOGIC TOOL; AEGYPTI SALIVA; EXPOSURE; VECTOR; ANTIGENS; RISK; MANNOSYLATION;

D O I：

10.1111/imb.12032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Study of the human antibody (Ab) response to Aedes salivary proteins can provide new biomarkers to evaluate human exposure to vector bites. The identification of genus-and/or species-specific proteins is necessary to improve the accuracy of biomarkers. We analysed Aedes albopictus immunogenic salivary proteins by 2D immunoproteomic technology and compared the profiles according to human individual exposure to Ae. albopictus or Ae. aegypti bites. Strong antigenicity to Ae. albopictus salivary proteins was detected in all individuals whatever the nature of Aedes exposure. Amongst these antigenic proteins, 68% are involved in blood feeding, including D7 protein family, adenosine deaminase, serpin and apyrase. This study provides an insight into the repertoire of Ae. albopictus immunogenic salivary proteins for the first time.

引用

页码：411 / 423

页数：13

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