Polymer monolithic capillary microextraction combined on-line with inductively coupled plasma MS for the determination of trace rare earth elements in biological samples

被引:38
作者
Zhang, Lin [1 ]
Chen, Beibei [1 ]
He, Man [1 ]
Hu, Bin [1 ]
机构
[1] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Analyt Chem Biol & Med, Wuhan 430072, Peoples R China
基金
中国博士后科学基金;
关键词
Biological samples; Capillary microextraction; Inductively coupled plasma mass spectrometry; Polymer monolith; Rare earth elements; CHELATING RESIN PRECONCENTRATION; FLOW-INJECTION PRECONCENTRATION; MASS-SPECTROMETRY; ICP-MS; BLOOD-SERUM; SEAWATER; EXTRACTION; CHROMATOGRAPHY; LANTHANIDES; ENRICHMENT;
D O I
10.1002/jssc.201300100
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A rapid and sensitive method based on polymer monolithic capillary microextraction combined on-line with microconcentric nebulization inductively coupled plasma MS has been developed for the determination of trace/ultratrace rare earth elements in biological samples. For this purpose, the iminodiacetic acid modified poly(glycidyl methacrylate-trimethylolpropane trimethacrylate) monolithic capillary was prepared and characterized by SEM and FTIR spectroscopy. Factors affecting the extraction efficiency, such as sample pH, sample flow rate, sample/eluent volume, and coexisting ions were investigated in detail. Under the optimal conditions, the LODs for rare earth elements were in the range of 0.08 (Er) to 0.97 ng/L (Nd) with a sampling frequency of 8.5 h(-1), and the RSDs were between 1.5% (Sm) and 7.4% (Nd) (c = 20 ng/L, n = 7). The proposed method was successfully applied to the analysis of trace/ultratrace rare earth elements in human urine and serum samples, and the recoveries for the spiked samples were in the range of 82-105%. The developed method was simple, rapid, sensitive, and favorable for the analysis of trace/ultratrace rare earth elements in biological samples with limited sample volume.
引用
收藏
页码:2158 / 2167
页数:10
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