Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress

被引：305

作者：

Sidossis, Labros S. ^{[1
,2
,3
,4
,5
]}

Porter, Craig ^{[1
,5
]}

Saraf, Manish K. ^{[1
,5
]}

Borsheim, Elisabet ^{[1
,5
]}

Radhakrishnan, Ravi S. ^{[5
]}

Chao, Tony ^{[1
,6
]}

Ali, Arham ^{[5
]}

Chondronikola, Maria ^{[1
,6
]}

Mlcak, Ronald ^{[5
]}

Finnerty, Celeste C. ^{[4
,5
,7
]}

Hawkins, Hal K. ^{[8
]}

Toliver-Kinsky, Tracy ^{[9
]}

Herndon, David N. ^{[1
,5
]}

机构：

[1] Shriners Hosp Children, Metab Unit, Galveston, TX 77550 USA

[2] Harokopio Univ, Dept Nutr & Dietet, Kallithea 17676, Greece

[3] Univ Texas Med Branch, Dept Internal Med, Galveston, TX 77550 USA

[4] Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77550 USA

[5] Univ Texas Med Branch, Dept Surg, Galveston, TX 77550 USA

[6] Univ Texas Med Branch, Dept Prevent Med & Community Hlth, Galveston, TX 77550 USA

[7] Univ Texas Med Branch, Sealy Ctr Mol Med, Galveston, TX 77550 USA

[8] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77550 USA

[9] Univ Texas Med Branch, Dept Anesthesiol, Galveston, TX 77550 USA

来源：

CELL METABOLISM | 2015年 / 22卷 / 02期

基金：

美国国家卫生研究院;

关键词：

BURN INJURY; GLUCOSE-HOMEOSTASIS; BEIGE ADIPOGENESIS; ADULT HUMANS; ADIPOCYTES; FAT; HYPERMETABOLISM; MITOCHONDRIA; ENERGY; EXPRESSION;

D O I：

10.1016/j.cmet.2015.06.022

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since the presence of brown adipose tissue (BAT) was confirmed in adult humans, BAT has become a therapeutic target for obesity and insulin resistance. We examined whether human subcutaneous white adipose tissue (sWAT) can adopt a BAT-like phenotype using a clinical model of prolonged and severe adrenergic stress. sWAT samples were collected from severely burned and healthy individuals. A subset of burn victims were prospectively followed during their acute hospitalization. Browning of sWAT was determined by the presence of multilocular adipocytes, uncoupling protein 1 (UCP1), and increased mitochondrial density and respiratory capacity. Multilocular UCP1-positive adipocytes were found in sWAT samples from burn patients. UCP1 mRNA, mitochondrial density, and leak respiratory capacity in sWAT increased after burn trauma. Our data demonstrate that human sWAT can transform from an energy-storing to an energy-dissipating tissue, which opens new research avenues in our quest to prevent and treat obesity and its metabolic complications.

引用

页码：219 / 227

页数：9

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