Imaging structural and functional brain development in early childhood

被引:640
作者
Gilmore, John H. [1 ]
Knickmeyer, Rebecca C. [1 ]
Gao, Wei [2 ,3 ]
机构
[1] Univ N Carolina, Sch Med, Dept Psychiat, CB 7160, Chapel Hill, NC USA
[2] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Dept Biomed Sci & Imaging, Los Angeles, CA USA
[3] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA
基金
美国国家卫生研究院;
关键词
WHITE-MATTER MICROSTRUCTURE; RESTING-STATE NETWORKS; TERM-EQUIVALENT AGE; DIFFUSION TENSOR; SEX-DIFFERENCES; INFANT BRAIN; GRAY-MATTER; THALAMOCORTICAL CONNECTIVITY; LONGITUDINAL DEVELOPMENT; FRACTIONAL ANISOTROPY;
D O I
10.1038/nrn.2018.1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In humans, the period from term birth to similar to 2 years of age is characterized by rapid and dynamic brain development and plays an important role in cognitive development and risk of disorders such as autism and schizophrenia. Recent imaging studies have begun to delineate the growth trajectories of brain structure and function in the first years after birth and their relationship to cognition and risk of neuropsychiatric disorders. This Review discusses the development of grey and white matter and structural and functional networks, as well as genetic and environmental influences on early-childhood brain development. We also discuss initial evidence regarding the usefulness of early imaging biomarkers for predicting cognitive outcomes and risk of neuropsychiatric disorders.
引用
收藏
页码:123 / 137
页数:15
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