A Multidisciplinary Approach to the Treatment of Anti-NMDA-Receptor Antibody Encephalitis: A Case and Review of the Literature

被引：48

作者：

Mann, Andrea ^{[1
]}

Machado, Nikolas Mata ^{[2
]}

Liu, Ni ^{[1
]}

Mazin, Abdul-Hussein ^{[2
]}

Silver, Kenneth ^{[2
]}

Afzal, Khalid I. ^{[1
]}

机构：

[1] Univ Chicago Med Ctr, Dept Psychiat & Behav Neuroscie, Chicago, IL USA

[2] Univ Chicago Med Ctr, Sect Pediat Neurol, Chicago, IL USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2012年 / 24卷 / 02期

关键词：

LIMBIC ENCEPHALITIS; OVARIAN TERATOMA; ELECTROCONVULSIVE-THERAPY; CATATONIA; DISORDERS; PSYCHOSIS; PATIENT;

D O I：

10.1176/appi.neuropsych.11070151

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Anti-NMDAR (N-methyl-d-aspartate receptor) encephalitis is a novel autoimmune and paraneoplastic disease often presenting as acute psychosis. Few studies exist in the psychiatric literature on neuroimmunity and behavioral management. This article reviews the epidemiology, diagnosis, pathophysiology, and management of this disease from a neuropsychiatric perspective. Patients have potential for near-complete recovery with early diagnosis and intervention. In addition to immune-suppression and tumor removal, electroconvulsive therapy may be an important tool in treatment of the underlying process in cases developing life-threatening catatonia. Psychiatrists should be familiar with treatment options, since they may be consulted within the context of a multispecialty team. (The Journal of Neuropsychiatry and Clinical Neurosciences 2012; 24:247-254)

引用

页码：247 / 254

页数：8

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