Natural gypenosides: targeting cancer through different molecular pathways

被引：13

作者：

Ahmad, Bashir ^{[1
,2
]}

Khan, Suliman ^{[1
,3
,4
]}

Nabi, Ghulam ^{[4
,5
]}

Gamallat, Yaser ^{[2
]}

Su, Pengyu ^{[2
]}

Jamalat, Yazeed ^{[2
]}

Duan, Pengfei ^{[1
,3
]}

Yao, Lunguang ^{[1
,3
]}

机构：

[1] Nanyang Normal Univ, Henan Prov Engn Res Ctr Hlth Prod Livestock & Pou, Nanyang, Peoples R China

[2] Dalian Med Univ, Coll Basic Med Sci, Dalian, Peoples R China

[3] Nanyang Normal Univ, Sch Agr Engn, Collaborat Innovat Ctr Water Secur Water Source R, Divers Project Henan Prov,Key Lab Ecol Secur Wate, Nanyang, Peoples R China

[4] Univ Chinese Acad Sci, Beijing, Peoples R China

[5] Chinese Acad Sci, Inst Hydrobiol, 7 South Rd East Lake, Wuhan 430072, Hubei, Peoples R China

来源：

CANCER MANAGEMENT AND RESEARCH | 2019年 / 11卷

基金：

美国国家科学基金会;

关键词：

cancer; surgery; chemotherapy; radiation therapy; Gyp; oral; lung; leukemic; colorectal; hepatocellular; NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; GYNOSTEMMA-PENTAPHYLLUM SAPONINS; MITOCHONDRIA-DEPENDENT PATHWAYS; INDUCED G0/G1 ARREST; G2/M PHASE ARREST; CELLS IN-VITRO; MEDIATED APOPTOSIS; SIGNALING PATHWAYS; HERBAL MEDICINES;

D O I：

10.2147/CMAR.S185232

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The second foremost cause of mortality around the word is cancer. Conventional therapies, such as radiation, surgery, and chemotherapy have limited accessibility owing to secondary resistance. Therefore, convenient, safe, and nonresistant drugs are urgently needed. Plant-derived natural products have attracted considerable interest owing to their high efficacy, low toxicity, and convenience. Gypenosides (Gyp) inhibit invasion, migration, metastasis, and proliferation and induce apoptosis in different cancers, including oral, lung, colorectal, hepatocellular, and leukemic cancers through different molecular pathways. This review summarizes Gyp studies on cancer to serve as a reference for further research and clinical trials.

引用

页码：2287 / 2297

页数：11

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