Simultaneous Determination of Four Tanshinones by UPLC-TQ/MS and Their Pharmacokinetic Application after Administration of Single Ethanol Extract of Danshen Combined with Water Extract in Normal and Adenine-Induced Chronic Renal Failure Rats

被引:19
作者
Cai, Hong-Die [1 ,2 ]
Su, Shu-Lan [1 ,2 ]
Li, Yonghui [3 ]
Zhu, Zhenhua [1 ,2 ]
Guo, Jianming [1 ,2 ]
Zhu, Yue [1 ,2 ]
Guo, Sheng [1 ,2 ]
Qian, Dawei [1 ,2 ]
Duan, Jinao [1 ,2 ]
机构
[1] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Natl & Local Collaborat Engn Ctr Chinese Med Reso, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Chinese Med, Jiangsu Key Lab High Technol Res TCM Formulae, Nanjing 210023, Jiangsu, Peoples R China
[3] Hainan Med Univ, Hainan Prov Key Lab R&D Trop Herbs, Sch Pharm, Haikou 571199, Peoples R China
基金
中国国家自然科学基金;
关键词
Salvia miltiorrhiza Bge; tanshinones; pharmacokinetics; UPLC-TQ/MS; chronic renal failure; SALVIANOLIC ACID B; DIHYDROTANSHINONE-I; MASS-SPECTROMETRY; IIA; CRYPTOTANSHINONE; MILTIORRHIZA; PLASMA; GROWTH; MS/MS;
D O I
10.3390/molecules21121630
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Salvia miltiorrhiza, one of the major traditional Chinese medicines, is commonly used and the main active ingredients-tanshinones-possess the ability to improve renal function. In this paper, the UPLC-TQ/MS method of simultaneously determining four tanshinones-tanshinone IIA, dihydrotanshinone I, tanshinone I, and cryptotanshinone-was established and applied to assess the pharmacokinetics in normal and chronic renal failure (CRF) rat plasma. The pharmacokinetics of tanshinones in rats were studied after separately intragastric administration of Salvia miltiorrhiza ethanol extract (SMEE) (0.65 g/kg), SMEE (0.65 g/kg) combined with Salvia miltiorrhiza water extract (SMWE) (1.55 g/kg). The results showed C-max and AUC(0-t) of tanshinone IIA, tanshinone I, cryptotanshinone reduced by 50%similar to 80% and CLz/F increased by 2 similar to 4 times (p < 0.05) in model group after administrated with SMEE. Nevertheless, after intragastric administration of a combination of SMWE and SMEE, the C-max and AUC(0-t) of four tanshinones were upregulated and CLz/F was downregulated, which undulated similarity from the model group to the normal group with compatibility of SMEE and SMWE. These results hinted that SMWE could improve the bioavailability of tanshinones in CRF rats, which provides scientific information for further exploration the mechanism of the combination of SMWE and SMEE and offers a reference for clinical administration of Salvia miltiorrhiza.
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页数:13
相关论文
共 34 条
[1]  
Bansal SK, 2010, BIOANALYSIS, V2, P685, DOI [10.4155/bio.10.39, 10.4155/BIO.10.39]
[2]   Effect of salvianolic acid B on TNF-alpha induced cerebral microcirculatory changes in a micro-invasive mouse model [J].
Chen, Bo ;
Sun, Kai ;
Liu, Yu-Ying ;
Xu, Xiang-Shun ;
Wang, Chuan-She ;
Zhao, Ke-Seng ;
Huang, Qiao-Bing ;
Han, Jing-Yan .
CHINESE JOURNAL OF TRAUMATOLOGY, 2016, 19 (02) :85-93
[3]   Combination of chlorogenic acid and salvianolic acid B protects against polychlorinated biphenyls-induced oxidative stress through Nrf2 [J].
Chen, Lijun ;
Li, Yuan ;
Yin, Wenqin ;
Shan, Wenqi ;
Dai, Jinfeng ;
Yang, Ye ;
Li, Lei .
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2016, 46 :255-263
[4]   Danshen: A versatile Chinese herbal drug for the treatment of coronary heart disease [J].
Cheng, Tsung O. .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2006, 113 (03) :437-438
[5]   Salvianolic acid B ameliorates CNS autoimmunity by suppressing Th1 responses [J].
Dong, Zhihui ;
Ma, Dihui ;
Gong, Ye ;
Yu, Tingmin ;
Yao, Gang .
NEUROSCIENCE LETTERS, 2016, 619 :92-99
[6]   Amelioration of Danhong iniection on the lipopolysaccharide-stimulated systemic acute inflammatory reaction via multi-target strategy [J].
Gao, Li-Na ;
Cui, Yuan-Lu ;
Wang, Qiang-Song ;
Wang, Shao-Xia .
JOURNAL OF ETHNOPHARMACOLOGY, 2013, 149 (03) :772-782
[7]   Anti-hypertensive effect of water extract of Danshen on renovascular hypertension through inhibition of the renin angiotensin system [J].
Kang, DG ;
Yun, YG ;
Ryoo, JH ;
Lee, HS .
AMERICAN JOURNAL OF CHINESE MEDICINE, 2002, 30 (01) :87-93
[8]   Cellular uptake and anticancer activity of salvianolic acid B phospholipid complex leaded nanoparticles in head and neck cancer and precancer cells [J].
Li, Hongquan ;
Shi, Linjun ;
Wei, Jie ;
Zhang, Chenping ;
Zhou, Zengtong ;
Wu, Lan ;
Liu, Wei .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 147 :65-72
[9]   ARP2/3 complex is required for directional migration of neural stem cell-derived oligodendrocyte precursors in electric fields [J].
Li, Yongchao ;
Wang, Pei-Shan ;
Lucas, George ;
Li, Rong ;
Yao, Li .
Stem Cell Research & Therapy, 2015, 6
[10]  
Liu TM, 2012, THESIS