Controlled-release biodegradable nanoparticles: From preparation to vaginal applications

被引：46
|
作者：
Martinez-Perez, Beatriz [1 ]
Quintanar-Guerrero, David [2 ]
Tapia-Tapia, Melina [3 ]
Cisneros-Tamayo, Ricardo [4 ]
Zambrano-Zaragoza, Maria L. [5 ]
Alcala-Alcala, Sergio [6 ]
Mendoza-Munoz, Nestor [7 ]
Pinon-Segundo, Elizabeth [1 ]
机构：
[1] UNAM, Fac Estudios Super Cuautitlan FES Cuautitlan, Lab Sistemas Farmaceut Liberac Modificada, Km 2-5 Carretera Cuautitlan Teoloyucan, Cuautitlan 54714, Edo De Mexico, Mexico
[2] UNAM, FES Cuautitlan, Lab Posgrad Tecnol Farmaceut, Av 1o Mayo S-N, Cuautitlan 54740, Edo De Mexico, Mexico
[3] UNAM, UAEM, CCIQS, Unidad San Cayetano, Carretera Toluca Atlacomulco Km 14-5, Toluca 50200, Edo De Mexico, Mexico
[4] Univ Politecn Valle Mexico, Univ Politecn, Div Ingn Nanotecnol, Av Mexiquense S-N, Tultitlan 54910, Edo De Mexico, Mexico
[5] UNAM, FES Cuautitlan, Lab Proc Transformac & Tecnol Emergentes Alimento, Km 2-5 Carretera Cuautitlan Teoloyucan, Cuautitlan 54714, Edo De Mexico, Mexico
[6] Univ Autonoma Estado Morelos, Fac Farm, Av Univ 1001, Cuernavaca 62209, Morelos, Mexico
[7] Univ Colima, Fac Ciencias Quim, Lab Farm, Carretera Colima Coquimatlan Km 9, Coquimatlan 28400, Colima, Mexico
来源：
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 115卷
关键词：
Biodegradable nanoparticles; Clotrimazole; Mucoadhesion; PLGA-chitosan nanoparticles; Vaginal administration; MODIFIED PLGA NANOPARTICLES; DRUG-DELIVERY-SYSTEMS; MOLECULAR-WEIGHT; CHITOSAN; MUCOADHESIVE; CLOTRIMAZOLE; ADSORPTION; SURFACE; DIFFUSION; POLYMERS;
D O I：
10.1016/j.ejps.2017.11.029
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This study aimed to prepare poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) with chitosan (CTS) surface modification to be used as a vaginal delivery system for antimycotic drugs. Clotrimazole was encapsulated with entrapment efficiencies of 86.1 and 68.9% into Clotrimazole-PLGA-NPs (CLT-PLGA-NPs) and PLGA-NPs with CTS-modified surface (CLT-PLGA-CTS-NPs), respectively. The later NPs exhibited a larger size and higher positive zeta potential (Z potential) in comparison to unmodified NPs. In vitro release kinetic studies indicated that Clotrimazole was released in percentages of > 98% from both nanoparticulate systems after 18 days. Antifungal activity and mucoadhesive properties of NPs were enhanced when CTS was added onto the surface. In summary, these results suggested that Clotrimazole loaded into PLGA-CTS-NPs has great potential for vaginal applications in treating vaginal infections generated by Candida albicans.
引用
收藏
页码：185 / 195
页数：11
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