Optical Coherence Tomography Angiography of RPGR- Associated Retinitis Pigmentosa Suggests Foveal Avascular Zone is a Biomarker for Vision Loss

被引：5

作者：

Tang, Peter H. ^{[1
,2
]}

Jauregui, Ruben ^{[3
,4
,5
,6
]}

Tsang, Stephen H. ^{[3
,4
,5
]}

Bassuk, Alexander G. ^{[7
]}

Mahajan, Vinit B. ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Byers Eye Inst, Om Lab,Dept Ophthalmol, Palo Alto, CA 94304 USA

[2] Palo Alto Vet Adm, Palo Alto, CA USA

[3] Columbia Univ, Dept Ophthalmol, Coll Phys & Surg, Bernard & Shirlee Brown Glaucoma Lab, New York, NY 10027 USA

[4] Columbia Univ, Dept Pathol, Coll Phys & Surg, Bernard & Shirlee Brown Glaucoma Lab, New York, NY USA

[5] Columbia Univ, Dept Cell Biol, Coll Phys & Surg, Bernard & Shirlee Brown Glaucoma Lab, New York, NY USA

[6] Weill Cornell Med Coll, New York, NY USA

[7] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA

来源：

OPHTHALMIC SURGERY LASERS & IMAGING RETINA | 2019年 / 50卷 / 02期

关键词：

QUANTITATIVE-ANALYSIS; ACUITY; AREA;

D O I：

10.3928/23258160-20190129-18

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

RPGR-associated retinitis pigmentosa (RP) is a progressive disease with retina degeneration. Optical coherence tomography angiography (OCTA) is an imaging technique that provides novel insights. The authors report two affected male siblings who underwent OCTA imaging. The area of the fovea! avascular zone (FAZ) was measured. Although the younger sibling exhibited more advanced clinical disease, his visual acuity was superior to his older sibling. OCTA imaging revealed a better preserved FAZ in the younger sibling as the reason for this. It also highlighted attenuation of choriocapillaris / choroid layers as biomarkers for disease severity. This provides new insights into retinal degeneration in RPGR-associated RP.

引用

页码：E44 / E48

页数：5

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